Yuhua Feng1, Meizuo Zhong1, Yiping Liu1, Leyuan Wang2, Youhong Tang3. 1. Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. 2. Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. 3. Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. fyh87256630@163.com.
Abstract
OBJECTIVE: To investigate the expression of TIM-3 and LAG-3 in extranodal NK/T cell lymphoma, nasal type (ENKTL), and evaluate the clinical and prognostic significance of TIM-3 and LAG-3 in ENKTL. METHODS: A total of 61 human paraffin-embedded specimens including 41 ENKTL and 20 rhinitis were involved. We performed immunohistochemistry to detect the expression of TIM-3 and LAG-3. We analyzed correlation between expression of TIM-3 and LAG-3 and clinicopathological features of ENKTL. RESULTS: TIM-3 was positively expressed in 95 (39/41) ENKTL compared with 55% (11/20) in rhinitis, LAG-3 was positively expressed in 95 (39/41) ENKTL compared with 45% (9/20) in rhinitis. A positive correlation was found between TIM-3 and LAG-3. TIM-3 and LAG-3 had no significant correlation with ENKTL patients' age, gender, international prognostic index (IPI) score, B symptoms, LDH level, Ann Arbor stage and treatment regimens. High expression of TIM-3, high IPI score, elevated LDH level and late Ann Arbor stage were shown to be correlated with worse progression free survival (PFS). A multivariate COX regression model show that TIM-3 high expression rate was an independent prognostic factor for ENKTL patients' PFS. CONCLUSIONS: Our findings indicate that TIM-3 might be a promising predictive indicator for the ENKTL patients.
OBJECTIVE: To investigate the expression of TIM-3 and LAG-3 in extranodal NK/T cell lymphoma, nasal type (ENKTL), and evaluate the clinical and prognostic significance of TIM-3 and LAG-3 in ENKTL. METHODS: A total of 61 humanparaffin-embedded specimens including 41 ENKTL and 20 rhinitis were involved. We performed immunohistochemistry to detect the expression of TIM-3 and LAG-3. We analyzed correlation between expression of TIM-3 and LAG-3 and clinicopathological features of ENKTL. RESULTS:TIM-3 was positively expressed in 95 (39/41) ENKTL compared with 55% (11/20) in rhinitis, LAG-3 was positively expressed in 95 (39/41) ENKTL compared with 45% (9/20) in rhinitis. A positive correlation was found between TIM-3 and LAG-3. TIM-3 and LAG-3 had no significant correlation with ENKTL patients' age, gender, international prognostic index (IPI) score, B symptoms, LDH level, Ann Arbor stage and treatment regimens. High expression of TIM-3, high IPI score, elevated LDH level and late Ann Arbor stage were shown to be correlated with worse progression free survival (PFS). A multivariate COX regression model show that TIM-3 high expression rate was an independent prognostic factor for ENKTL patients' PFS. CONCLUSIONS: Our findings indicate that TIM-3 might be a promising predictive indicator for the ENKTL patients.
Authors: Won Seog Kim; Yasuhiro Oki; Seok Jin Kim; Sang Eun Yoon; Kirit M Ardeshna; Yi Lin; Jia Ruan; Pierluigi Porcu; Jonathan E Brammer; Eric D Jacobsen; Dok Hyun Yoon; Cheolwon Suh; Felipe Suarez; John Radford; Lihua E Budde; Jin Seok Kim; Emmanuel Bachy; Hun Ju Lee; Catherine M Bollard; Arnaud Jaccard; Hye Jin Kang; Shannon Inman; Maryann Murray; Katherin E Combs; Daniel Y Lee; Ranjana Advani; Kurt C Gunter; Cliona M Rooney; Helen E Heslop Journal: Ann Hematol Date: 2021-07-24 Impact factor: 3.673