Literature DB >> 28900908

The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel.

Aparna Gudlur1, Patrick G Hogan2.   

Abstract

This chapter focuses on the Orai proteins, Orai1-Orai3, with special emphasis on Orai1, in humans and other mammals, and on the definitive evidence that Orai is the pore subunit of the CRAC channel. It begins by reviewing briefly the defining characteristics of the CRAC channel, then discusses the studies that implicated Orai as part of the store-operated Ca2+ entry pathway and as the CRAC channel pore subunit, and finally examines ongoing work that is providing insights into CRAC channel structure and gating.

Entities:  

Keywords:  CRAC channel; CRAC current; Calcium channel; Calcium conductance; Gating; Orai1; STIM1

Mesh：

Substances：

Year:  2017        PMID： 28900908      PMCID： PMC5764705          DOI： 10.1007/978-3-319-57732-6_3

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  96 in total

1.  Orai1 and STIM reconstitute store-operated calcium channel function.

Authors:  Jonathan Soboloff; Maria A Spassova; Xiang D Tang; Thamara Hewavitharana; Wen Xu; Donald L Gill
Journal:  J Biol Chem       Date:  2006-06-09       Impact factor: 5.157

2.  Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1.

Authors:  Pingyong Xu; Jingze Lu; Zhengzheng Li; Xiaoqing Yu; Liangyi Chen; Tao Xu
Journal:  Biochem Biophys Res Commun       Date:  2006-10-04       Impact factor: 3.575

3.  Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.

Authors:  Irene Frischauf; Martin Muik; Isabella Derler; Judith Bergsmann; Marc Fahrner; Rainer Schindl; Klaus Groschner; Christoph Romanin
Journal:  J Biol Chem       Date:  2009-06-08       Impact factor: 5.157

4.  Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions.

Authors:  P T Ellinor; J Yang; W A Sather; J F Zhang; R W Tsien
Journal:  Neuron       Date:  1995-11       Impact factor: 17.173

5.  Genetically targeted single-channel optical recording reveals multiple Orai1 gating states and oscillations in calcium influx.

Authors:  Joseph L Dynes; Anna Amcheslavsky; Michael D Cahalan
Journal:  Proc Natl Acad Sci U S A       Date:  2015-12-28       Impact factor: 11.205

6.  Potentiation and inhibition of Ca(2+) release-activated Ca(2+) channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptors.

Authors:  M Prakriya; R S Lewis
Journal:  J Physiol       Date:  2001-10-01       Impact factor: 5.182

7.  The Orai1 Store-operated Calcium Channel Functions as a Hexamer.

Authors:  Xiangyu Cai; Yandong Zhou; Robert M Nwokonko; Natalia A Loktionova; Xianming Wang; Ping Xin; Mohamed Trebak; Youjun Wang; Donald L Gill
Journal:  J Biol Chem       Date:  2016-10-25       Impact factor: 5.157

8.  Cholesterol modulates Orai1 channel function.

Authors:  Isabella Derler; Isaac Jardin; Peter B Stathopulos; Martin Muik; Marc Fahrner; Vasilina Zayats; Saurabh K Pandey; Michael Poteser; Barbara Lackner; Marketa Absolonova; Rainer Schindl; Klaus Groschner; Rüdiger Ettrich; Mitsu Ikura; Christoph Romanin
Journal:  Sci Signal       Date:  2016-01-26       Impact factor: 8.192

9.  Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback.

Authors:  A Zweifach; R S Lewis
Journal:  J Gen Physiol       Date:  1995-02       Impact factor: 4.086

10.  Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding.

Authors:  Leidamarie Tirado-Lee; Megumi Yamashita; Murali Prakriya
Journal:  PLoS One       Date:  2015-06-02       Impact factor: 3.240
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  6 in total

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Authors:  Yaping Wang; Jian Shi; Xiaoyong Tong
Journal:  Int J Mol Sci       Date:  2021-08-16       Impact factor: 5.923

2.  A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions.

Authors:  Iman Azimi; Ralph J Stevenson; Xuexin Zhang; Aldo Meizoso-Huesca; Ping Xin; Martin Johnson; Jack U Flanagan; Silke B Chalmers; Ryan E Yoast; Jeevak S Kapure; Benjamin P Ross; Irina Vetter; Mark R Ashton; Bradley S Launikonis; William A Denny; Mohamed Trebak; Gregory R Monteith
Journal:  ACS Pharmacol Transl Sci       Date:  2020-01-13

3.  FOXO1 transcription factor plays a key role in T cell-HIV-1 interaction.

Authors:  Arthur Roux; Héloise Leroy; Bénédicte De Muylder; Lucie Bracq; Samia Oussous; Isabelle Dusanter-Fourt; Ghina Chougui; Rachida Tacine; Clotilde Randriamampita; Delphine Desjardins; Roger Le Grand; Frederic Bouillaud; Serge Benichou; Florence Margottin-Goguet; Remi Cheynier; Georges Bismuth; Marianne Mangeney
Journal:  PLoS Pathog       Date:  2019-05-01       Impact factor: 6.823

4.  Septins organize endoplasmic reticulum-plasma membrane junctions for STIM1-ORAI1 calcium signalling.

Authors:  Zachary B Katz; Chen Zhang; Ariel Quintana; Björn F Lillemeier; Patrick G Hogan
Journal:  Sci Rep       Date:  2019-07-25       Impact factor: 4.379

5.  X-ray irradiation triggers immune response in human T-lymphocytes via store-operated Ca2+ entry and NFAT activation.

Authors:  Dominique Tandl; Tim Sponagel; Dalia Alansary; Sebastian Fuck; Timo Smit; Stephanie Hehlgans; Burkhard Jakob; Claudia Fournier; Barbara A Niemeyer; Franz Rödel; Bastian Roth; Anna Moroni; Gerhard Thiel
Journal:  J Gen Physiol       Date:  2022-04-13       Impact factor: 4.000

6.  A549 in-silico 1.0: A first computational model to simulate cell cycle dependent ion current modulation in the human lung adenocarcinoma.

Authors:  Sonja Langthaler; Theresa Rienmüller; Susanne Scheruebel; Brigitte Pelzmann; Niroj Shrestha; Klaus Zorn-Pauly; Wolfgang Schreibmayer; Andrew Koff; Christian Baumgartner
Journal:  PLoS Comput Biol       Date:  2021-06-22       Impact factor: 4.779
  6 in total

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