Johannah Linda Shergis1, Xiaojia Ni2, Jerome Sarris3, Anthony Lin Zhang1, Xinfeng Guo4, Charlie C Xue2, Chuanjian Lu5, Helmut Hugel6. 1. China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, PO Box 71, Bundoora 3083, Australia. 2. China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, PO Box 71, Bundoora 3083, Australia; Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, 111 Dade Road, Yuexiu District, Guangzhou 510120, PR China. 3. Department of Psychiatry and The Melbourne Clinic, The University of Melbourne, Victoria 3121, Australia; Centre for Human Psychopharmacology, Swinburne University of Technology, PO Box 218, Hawthorn 3122, Victoria, Australia. 4. Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, 111 Dade Road, Yuexiu District, Guangzhou 510120, PR China. 5. Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, 111 Dade Road, Yuexiu District, Guangzhou 510120, PR China. Electronic address: luchuanjian888@vip.sina.com. 6. School of Science, RMIT University, PO Box 2476, Melbourne 3001 VIC, Australia. Electronic address: hugel@rmit.edu.au.
Abstract
BACKGROUND: In Chinese medicine, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou is widely used for the treatment of insomnia. PURPOSE/SECTIONS: This paper summarises the chemistry, psychopharmacology, and compares the pharmaceutical effects of the seeds of Ziziphus jujuba plant, Ziziphus spinosa (ZS) seeds, with benzodiazepines. Whole extracts and constituent compounds have been evaluated in preclinical and clinical studies. CONCLUSIONS: ZS secondary metabolites modulate GABAergic activity and the serotonergic system. The actual therapeutic agents require further confirmation/identification so that new insomnia phytomedicines can be discovered.
BACKGROUND: In Chinese medicine, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou is widely used for the treatment of insomnia. PURPOSE/SECTIONS: This paper summarises the chemistry, psychopharmacology, and compares the pharmaceutical effects of the seeds of Ziziphus jujuba plant, Ziziphus spinosa (ZS) seeds, with benzodiazepines. Whole extracts and constituent compounds have been evaluated in preclinical and clinical studies. CONCLUSIONS: ZS secondary metabolites modulate GABAergic activity and the serotonergic system. The actual therapeutic agents require further confirmation/identification so that new insomnia phytomedicines can be discovered.
Authors: Li Bo Li; Young Woo Kim; Yu Hua Wang; Li Bai; Xiao Dong Zhu; Zheng Lin Zhao; Chul Won Lee; Yu Jiao; Tong Wu; Zhen Zhen Cai; Sang Chan Kim; Won G An; Chae Ha Yang; Guang Cheng Cui; Rong Jie Zhao Journal: BMC Complement Altern Med Date: 2019-06-24 Impact factor: 4.782