Jean Lowe1, Fares Qeadan2, Lawrence Leeman3, Shikhar Shrestha4, Julia M Stephen5, Ludmila N Bakhireva6. 1. Department of Pediatrics, University of New Mexico, Albuquerque, NM, USA. 2. Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA. 3. Department of Family and Community Medicine, University of New Mexico, Albuquerque, NM, USA; Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM, USA. 4. Department of Pharmacy Practice and Administrative Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA. 5. The Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA. 6. Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA; Department of Family and Community Medicine, University of New Mexico, Albuquerque, NM, USA; Department of Pharmacy Practice and Administrative Sciences, University of New Mexico College of Pharmacy, Albuquerque, NM, USA. Electronic address: lbakhireva@salud.unm.edu.
Abstract
BACKGROUND: The effects of prenatal substance exposure on neurobehavioral outcomes are inherently confounded by the effects of the postnatal environment, making it difficult to disentangle their influence. The goal of this study was to examine the contributing effects of prenatal substance use and parenting style (operationalized as contingent responding during the play episodes of the Still-face paradigm [SFP]) on infant affect. METHODS: A prospective cohort design was utilized with repeated assessment of substance use during pregnancy and the administration of the SFP, which measures infant response to a social stressor, at approximately 6months of age. Subjects included 91 dyads classified into four groups: 1) Control (n=34); 2) Medication assisted therapy for opioid dependence (MAT; n=19); 3) Alcohol (n=15); 4) Alcohol+MAT (n=23). Mean % of positive infant affect and mean % of maternal responsiveness (watching, attention seeking, and contingent responding) was compared among the five SFP episodes across the four study groups by MANOVA. Mixed effects modelling was used to estimate the contributing effects of the study groups and maternal responsiveness on infant affect. RESULTS: Maternal contingent responding was associated with increase (β̂=0.84; p<0.0001) and attention seeking with decrease (β̂=-0.78; p<0.0001) in infant positive affect. The combined effect of prenatal exposures and covariates explained 15.8% of the variability in infant positive affect, while the model including contingent responding and covariates explained 67.1% of the variability. CONCLUSIONS: Higher maternal responsiveness was a much stronger predictor of infant behavior than prenatal exposures, providing the basis for future intervention studies focusing on specific parenting strategies.
BACKGROUND: The effects of prenatal substance exposure on neurobehavioral outcomes are inherently confounded by the effects of the postnatal environment, making it difficult to disentangle their influence. The goal of this study was to examine the contributing effects of prenatal substance use and parenting style (operationalized as contingent responding during the play episodes of the Still-face paradigm [SFP]) on infant affect. METHODS: A prospective cohort design was utilized with repeated assessment of substance use during pregnancy and the administration of the SFP, which measures infant response to a social stressor, at approximately 6months of age. Subjects included 91 dyads classified into four groups: 1) Control (n=34); 2) Medication assisted therapy for opioid dependence (MAT; n=19); 3) Alcohol (n=15); 4) Alcohol+MAT (n=23). Mean % of positive infant affect and mean % of maternal responsiveness (watching, attention seeking, and contingent responding) was compared among the five SFP episodes across the four study groups by MANOVA. Mixed effects modelling was used to estimate the contributing effects of the study groups and maternal responsiveness on infant affect. RESULTS: Maternal contingent responding was associated with increase (β̂=0.84; p<0.0001) and attention seeking with decrease (β̂=-0.78; p<0.0001) in infant positive affect. The combined effect of prenatal exposures and covariates explained 15.8% of the variability in infant positive affect, while the model including contingent responding and covariates explained 67.1% of the variability. CONCLUSIONS: Higher maternal responsiveness was a much stronger predictor of infant behavior than prenatal exposures, providing the basis for future intervention studies focusing on specific parenting strategies.
Authors: E Z Tronick; D S Messinger; M K Weinberg; B M Lester; L Lagasse; R Seifer; C R Bauer; S Shankaran; H Bada; L L Wright; K Poole; J Liu Journal: Dev Psychol Date: 2005-09
Authors: Julie A Kable; Mary J O'Connor; Heather Carmichael Olson; Blair Paley; Sarah N Mattson; Sally M Anderson; Edward P Riley Journal: Child Psychiatry Hum Dev Date: 2016-04
Authors: Hilda L Gutierrez; Lauren Hund; Shikhar Shrestha; William F Rayburn; Lawrence Leeman; Daniel D Savage; Ludmila N Bakhireva Journal: Alcohol Date: 2015-07-21 Impact factor: 2.405
Authors: Ludmila N Bakhireva; Bradley D Holbrook; Shikhar Shrestha; Yuridia Leyva; Malia Ashley; Sandra Cano; Jean Lowe; Julia M Stephen; Lawrence Leeman Journal: Early Hum Dev Date: 2018-12-13 Impact factor: 2.079
Authors: Kathryn G Beauchamp; Jean Lowe; Ronald M Schrader; Shikhar Shrestha; Crystal Aragón; Natalia Moss; Julia M Stephen; Ludmila N Bakhireva Journal: Early Hum Dev Date: 2020-07-02 Impact factor: 2.079
Authors: Julia M Stephen; Lucinda Flynn; Danielle Kabella; Megan Schendel; Sandra Cano; Daniel D Savage; William Rayburn; Lawrence M Leeman; Jean Lowe; Ludmila N Bakhireva Journal: Neuroimage Clin Date: 2017-12-09 Impact factor: 4.881
Authors: Jean R Lowe; Lauren Hund; Dominique E Rodriguez; Asma Qamruddin; Lawrence Leeman; Julia M Stephen; Ludmila N Bakhireva Journal: Early Hum Dev Date: 2021-07-04 Impact factor: 2.699