Lionel Carbillon1, Heloise Gronier2, Isabelle Cedrin-Durnerin2, Isabelle Pharisien3, Minh T Nguyen4, Paul Valensi4, Emmanuel Cosson5. 1. Paris 13 University, Sorbonne Paris Cité, AP-HP, Jean Verdier Hospital, Department of Obstetrics and Gynecology, Bondy, France. Electronic address: lionel.carbillon@aphp.fr. 2. AP-HP, Jean Verdier Hospital, Department of Reproductive Medicine, Bondy, France. 3. Paris 13 University, Sorbonne Paris Cité, AP-HP, Jean Verdier Hospital, Department of Obstetrics and Gynecology, Bondy, France. 4. Paris 13 University, Sorbonne Paris Cité, AP-HP, Jean Verdier Hospital, Department of Endocrinology-Diabetology-Nutrition, CRNH-IdF, Bondy, France. 5. Paris 13 University, Sorbonne Paris Cité, AP-HP, Jean Verdier Hospital, Department of Endocrinology-Diabetology-Nutrition, CRNH-IdF, Bondy, France; Paris 13 University, Sorbonne Paris Cité, UMR U1153 INSERM/U11125 INRA/CNAM/Université Paris13, Unité de Recherche Epidémiologique Nutritionnelle, Bobigny, France.
Abstract
OBJECTIVES: To study the role of ovarian stimulation procedures on the risk of pregnancy-induced hypertension, gestational diabetes mellitus and neonatal outcomes according to women's characteristics and the causes of infertility. DESIGN: Retrospective, observational, case/control study. PATIENTS: Spontaneous pregnancies (group A, n=8107), pregnancies achieved after mild ovarian ovulation induction without other Assisted Reproductive Technology (ART) procedures (group B, n=44), pregnancies after mild ovarian stimulation and ART procedures (group C, n=53) or pregnancies after multi (>2) follicular stimulation with gonadotrophin therapy and ART procedures (group D, n=133); all of the groups had identical protocols for prenatal care. MAIN OUTCOME MEASUREMENTS: Pregnancy-induced hypertension (PIH), fetal macrosomia (estimated fetal weight >90th percentile), gestational diabetes mellitus, caesarean section, and neonatal outcomes. RESULTS: The incidence rates of PIH (2.7, 11.6, 4.2, and 2.5%) in groups A, B, C and D, respectively, (p=0.004), fetal macrosomia (4.7, 7.0, 20.8, and 7.6%, respectively, p<0.001), caesarean section (21.8, 37.2, 21.7, and 17.6%, respectively, p=0.048), differed among the groups. The high incidence of PIH in pregnancies following ovulation induction was driven by polycystic ovarian syndrome (PCOS) per se. CONCLUSION: PCOS per se was associated with more PIH, and ART procedures after mild mono/bi follicular ovarian stimulation were associated with more fetal macrosomia.
OBJECTIVES: To study the role of ovarian stimulation procedures on the risk of pregnancy-induced hypertension, gestational diabetes mellitus and neonatal outcomes according to women's characteristics and the causes of infertility. DESIGN: Retrospective, observational, case/control study. PATIENTS: Spontaneous pregnancies (group A, n=8107), pregnancies achieved after mild ovarian ovulation induction without other Assisted Reproductive Technology (ART) procedures (group B, n=44), pregnancies after mild ovarian stimulation and ART procedures (group C, n=53) or pregnancies after multi (>2) follicular stimulation with gonadotrophin therapy and ART procedures (group D, n=133); all of the groups had identical protocols for prenatal care. MAIN OUTCOME MEASUREMENTS: Pregnancy-induced hypertension (PIH), fetal macrosomia (estimated fetal weight >90th percentile), gestational diabetes mellitus, caesarean section, and neonatal outcomes. RESULTS: The incidence rates of PIH (2.7, 11.6, 4.2, and 2.5%) in groups A, B, C and D, respectively, (p=0.004), fetal macrosomia (4.7, 7.0, 20.8, and 7.6%, respectively, p<0.001), caesarean section (21.8, 37.2, 21.7, and 17.6%, respectively, p=0.048), differed among the groups. The high incidence of PIH in pregnancies following ovulation induction was driven by polycystic ovarian syndrome (PCOS) per se. CONCLUSION:PCOS per se was associated with more PIH, and ART procedures after mild mono/bi follicular ovarian stimulation were associated with more fetal macrosomia.
Authors: Nakeisha A Lodge-Tulloch; Flavia T S Elias; Jessica Pudwell; Laura Gaudet; Mark Walker; Graeme N Smith; Maria P Velez Journal: BMC Pregnancy Childbirth Date: 2021-03-22 Impact factor: 3.007
Authors: Mathilde Bourdon; Pietro Santulli; Chloé Maignien; Khaled Pocate-Cheriet; Asim Alwohaibi; Louis Marcellin; Sarah Blais; Charles Chapron Journal: PLoS One Date: 2018-10-19 Impact factor: 3.240