Literature DB >> 2889662

Genetic mapping of nine DNA markers in the q11----q22 region of the human X chromosome.

B Arveiler1, I Oberlé, J L Mandel.   

Abstract

We have ordered nine polymorphic DNA markers within detailed map of the proximal part of the human X chromosome long arm, extending from band q11 to q22, by use of both physical mapping with a panel of rodent-human somatic hybrids and multipoint linkage analysis. Analysis of 44 families (including 17 families from the Centre d'Etude du Polymorphisme Humain) provided highly significant linkage data for both order and estimation of map distances between loci. We have obtained the following order: DXS1-DXS159-DXYS1-DXYS12-DXS3-(DXS94 , DXS178)-DXYS17. The most probable location of DXYS2 is between DXS159 and DXS3, close to DXYS1 and DXYS12. The high density of markers (nine loci within 30 recombination units) and the improvement in the estimation of recombination frequencies should be very useful for multipoint mapping of disease loci in this region and for diagnostic applications.

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Year:  1987        PMID： 2889662     DOI： 10.1016/0888-7543(87)90105-4

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  20 in total

1.  X-linked Charcot-Marie-Tooth disease. A linkage study in a large family by using 12 probes of the pericentromeric region.

Authors:  M L Mostacciuolo; E Müller; P Fardin; G F Micaglio; B Bardoni; S Guioli; G Camerino; G A Danieli
Journal:  Hum Genet       Date:  1991-05       Impact factor: 4.132

2.  A recombination map of the human X-chromosome.

Authors:  R G Del Mastro; P A Farndon; M W Kilpatrick
Journal:  Hum Genet       Date:  1990-12       Impact factor: 4.132

3.  Allan-Herndon syndrome. II. Linkage to DNA markers in Xq21.

Authors:  C E Schwartz; J Ulmer; A Brown; I Pancoast; H O Goodman; R E Stevenson
Journal:  Am J Hum Genet       Date:  1990-09       Impact factor: 11.025

4.  A deletion panel of the long arm of the X chromosome: subregional localization of 22 DNA probes.

Authors:  H M Yang; T Lund; E Niebuhr; S Nørby; M Schwartz; L Shen
Journal:  Hum Genet       Date:  1990-06       Impact factor: 4.132

5.  Germ-line mosaicism simulates genetic heterogeneity in Wiskott-Aldrich syndrome.

Authors:  B Arveiler; G de Saint-Basile; A Fischer; C Griscelli; J L Mandel
Journal:  Am J Hum Genet       Date:  1990-05       Impact factor: 11.025

6.  The gene for X-linked progressive mixed deafness with perilymphatic gusher during stapes surgery (DFN3) is linked to PGK.

Authors:  H G Brunner; A van Bennekom; E M Lambermon; T L Oei; W R Cremers; B Wieringa; H H Ropers
Journal:  Hum Genet       Date:  1988-12       Impact factor: 4.132

7.  Linkage of PGK1 to X-linked severe combined immunodeficiency (IMD4) allows predictive testing in families with no surviving male.

Authors:  J Goodship; R Levinsky; S Malcolm
Journal:  Hum Genet       Date:  1989-12       Impact factor: 4.132

8.  Close linkage of probe p212 (DXS178) to X-linked agammaglobulinemia.

Authors:  S Guioli; B Arveiler; B Bardoni; L D Notarangelo; P Panina; M Duse; A Ugazio; I Oberlé; G de Saint Basile; J L Mandel
Journal:  Hum Genet       Date:  1989-12       Impact factor: 4.132

9.  Haplotype and multipoint linkage analysis in Finnish choroideremia families.

Authors:  E M Sankila; T Lehner; A W Eriksson; H Forsius; J Kärnä; D Page; J Ott; A de la Chapelle
Journal:  Hum Genet       Date:  1989-12       Impact factor: 4.132

10.  Molecular analysis of male-viable deletions and duplications allows ordering of 52 DNA probes on proximal Xq.

Authors:  F P Cremers; T J van de Pol; B Wieringa; M H Hofker; P L Pearson; R A Pfeiffer; M Mikkelsen; A Tabor; H H Ropers
Journal:  Am J Hum Genet       Date:  1988-10       Impact factor: 11.025
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