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Literature DB >> 28895782

Dendritic cells as natural latency reversing agent: A wake-up call for HIV-1.

T van Montfort¹, D Speijer², B Berkhout¹.

Abstract

Entities: Species

Keywords: HIV-1; dendritic cells; latency; latency reversing agent

Mesh：

Year: 2017 PMID： 28895782 PMCID： PMC5810499 DOI： 10.1080/21505594.2017.1371898

Source DB: PubMed Journal: Virulence ISSN： 2150-5594 Impact factor: 5.882

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29 in total

1. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy.

Authors: D Finzi; J Blankson; J D Siliciano; J B Margolick; K Chadwick; T Pierson; K Smith; J Lisziewicz; F Lori; C Flexner; T C Quinn; R E Chaisson; E Rosenberg; B Walker; S Gange; J Gallant; R F Siliciano
Journal: Nat Med Date: 1999-05 Impact factor: 53.440

2. Operating on chromatin, a colorful language where context matters.

Authors: Kathryn E Gardner; C David Allis; Brian D Strahl
Journal: J Mol Biol Date: 2011-01-25 Impact factor: 5.469

Review 3. HIV-1 pathogenesis.

Authors: Mario Stevenson
Journal: Nat Med Date: 2003-07 Impact factor: 53.440

4. Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands.

Authors: Angela Meier; Aranya Bagchi; Harlyn K Sidhu; Galit Alter; Todd J Suscovich; Daniel G Kavanagh; Hendrik Streeck; Mark A Brockman; Sylvie LeGall; Judith Hellman; Marcus Altfeld
Journal: AIDS Date: 2008-03-12 Impact factor: 4.177

5. HIV rebounds from latently infected cells, rather than from continuing low-level replication.

Authors: Beda Joos; Marek Fischer; Herbert Kuster; Satish K Pillai; Joseph K Wong; Jürg Böni; Bernard Hirschel; Rainer Weber; Alexandra Trkola; Huldrych F Günthard
Journal: Proc Natl Acad Sci U S A Date: 2008-10-20 Impact factor: 11.205

6. Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages.

Authors: George B Kyei; Christina Dinkins; Alexander S Davis; Esteban Roberts; Sudha B Singh; Chunsheng Dong; Li Wu; Eiki Kominami; Takashi Ueno; Akitsugu Yamamoto; Maurizio Federico; Antonito Panganiban; Isabelle Vergne; Vojo Deretic
Journal: J Cell Biol Date: 2009-07-27 Impact factor: 10.539

7. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.

Authors: Nicolas Chomont; Mohamed El-Far; Petronela Ancuta; Lydie Trautmann; Francesco A Procopio; Bader Yassine-Diab; Geneviève Boucher; Mohamed-Rachid Boulassel; Georges Ghattas; Jason M Brenchley; Timothy W Schacker; Brenna J Hill; Daniel C Douek; Jean-Pierre Routy; Elias K Haddad; Rafick-Pierre Sékaly
Journal: Nat Med Date: 2009-06-21 Impact factor: 53.440

Dendritic cells as natural latency reversing agent: A wake-up call for HIV-1.

1. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy.

2. Operating on chromatin, a colorful language where context matters.

Review 3. HIV-1 pathogenesis.

4. Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands.

5. HIV rebounds from latently infected cells, rather than from continuing low-level replication.

6. Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages.

7. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.

8. Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.

9. Dendritic cell-induced activation of latent HIV-1 provirus in actively proliferating primary T lymphocytes.

10. New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.

Review 1. Using Dendritic Cell-Based Immunotherapy to Treat HIV: How Can This Strategy be Improved?