Literature DB >> 2889472

Inhibition of erythrocyte transglutaminase by GTP.

C M Bergamini1, M Signorini, L Poltronieri.   

Abstract

The guanine nucleotides GTP, GDP and GMP inhibit the activity of erythrocyte transglutaminase (protein-glutamine:amine gamma-glutamyltransferase, EC 2.3.2.13) in a decreasing order of effectiveness. The inhibition is more apparent at low than at saturating levels of calcium ions and is not due to the chelation of Ca2+, but to an interference with the process of activation by the cation. This inhibition is likely to contribute to the latency of erythrocyte transglutaminase in physiological conditions.

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Year:  1987        PMID： 2889472     DOI： 10.1016/0167-4838(87)90222-6

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  12 in total

1.  Nucleotide binding by the erythrocyte transglutaminase/Gh protein, probed with fluorescent analogs of GTP and GDP.

Authors:  S N Murthy; L Lorand
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-05       Impact factor: 11.205

2.  Inhibition of rat liver transglutaminase by nucleotides.

Authors:  S Kawashima
Journal:  Experientia       Date:  1991-07-15

Review 3.  Transglutaminase is a therapeutic target for oxidative stress, excitotoxicity and stroke: a new epigenetic kid on the CNS block.

Authors:  Manuela Basso; Rajiv R Ratan
Journal:  J Cereb Blood Flow Metab       Date:  2013-04-10       Impact factor: 6.200

Review 4.  Role of transglutaminase 2 in celiac disease pathogenesis.

Authors:  Cornelius Klöck; Thomas R Diraimondo; Chaitan Khosla
Journal:  Semin Immunopathol       Date:  2012-03-22       Impact factor: 9.623

Review 5.  Regulation of the activities of the mammalian transglutaminase family of enzymes.

Authors:  Cornelius Klöck; Chaitan Khosla
Journal:  Protein Sci       Date:  2012-11-09       Impact factor: 6.725

6.  Conserved tryptophan in the core domain of transglutaminase is essential for catalytic activity.

Authors:  S N Prasanna Murthy; Siiri Iismaa; Gillian Begg; Douglas M Freymann; Robert M Graham; Laszlo Lorand
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-26       Impact factor: 11.205

Review 7.  Transglutaminase-mediated remodeling of the human erythrocyte membrane skeleton: relevance for erythrocyte diseases with shortened cell lifespan.

Authors:  Laszlo Lorand; S N Prasanna Murthy; Anwar A Khan; Weihua Xue; Oksana Lockridge; Athar H Chishti
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  2011

8.  Studies on tissue transglutaminases: interaction of erythrocyte type-2 transglutaminase with GTP.

Authors:  C M Bergamini; M Signorini
Journal:  Biochem J       Date:  1993-04-01       Impact factor: 3.857

9.  Immunological characterization and activity of transglutaminases in human normal and malignant prostate and in prostate cancer cell lines.

Authors:  B Friedrichs; H Riedmiller; H W Goebel; U Rausch; G Aumüller
Journal:  Urol Res       Date:  1995

Review 10.  Transglutaminases and neurodegeneration.

Authors:  Thomas M Jeitner; John T Pinto; Boris F Krasnikov; Mark Horswill; Arthur J L Cooper
Journal:  J Neurochem       Date:  2009-05       Impact factor: 5.372
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