| Literature DB >> 28894409 |
Jingli Zhang1, Habsah Mohamad2, Jia Hui Wong1, Muhammad Bilal1, Abdul Hadi Bin Ismail2, Amelia Jane Lloyd3,1, Abdul Aziz Mohamed Yusoff3,1, Hasnah Osman4, Kok Tong Wong4, Zamzuri Idris3,1,5, Jafri Malin Abdullah3,1,5.
Abstract
The α1β2γ2 subtype of GABAA receptors is the most commonly found GABAA receptor subtype in the mammalian cortex and hippocampus. It is expressed heterologously in the Xenopus laevis oocyte as a α1β2γ2S/L subtype for application as an in vitro model for the screening of compounds that modulate receptor activities. In fact, 4-hydroxybenzaldehyde (4-HB) has been identified as one of the major components in Dendrocalamus asper bamboo shoots in our previous study, and the current study showed that at 101.7 μM, 4-HB significantly reduced the GABA-induced chloride current of GABAA receptors expressed on Xenopus oocytes, indicating a possible GABAergic antagonistic effect at high concentrations.Entities:
Keywords: GABAergic agents; Xenopus oocytes; bamboo shoot; electrophysiology; α1β2γ2 GABAA receptor
Year: 2017 PMID： 28894409 PMCID： PMC5566067 DOI： 10.21315/mjms2017.24.2.12
Source DB: PubMed Journal: Malays J Med Sci ISSN： 1394-195X