Literature DB >> 28893740

An unusual presentation of chronic cyanide toxicity from self-prescribed apricot kernel extract.

Alex Konstantatos1, Malini Shiv Kumar1, Aidan Burrell1, Joel Smith1.   

Abstract

Hypoxia under general anaesthesia is a potentially life-threatening condition. A seemingly well 67-year-old man appeared hypoxic with peripheral pulse oximetric measurement during routine anaesthesia. Postoperatively, the patient admitted to daily self-prescription of apricot kernel extract for a period of 5 years. Apricot kernel is a commonly taken extract used for a range of ailments, and is associated with cyanide toxicity, which was confirmed through blood analysis. Our explanation for the hypoxic measurement was the presence of free cyanide interfering with functioning of the peripheral pulse oximeter. On cessation of the apricot kernel extract, peripheral oxygen saturations returned to normal. Cardiac and respiratory causes together with rare haemoglobinopathies were excluded. This case illustrates how chronic dosing of complementary medicines can result in harmful toxicities, which may carry potential for serious consequences and how these chronic toxicities may present to physicians in atypical ways. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Entities:  

Keywords:  anaesthesia; complementary medicine; poisoning; unwanted effects / adverse reactions

Mesh:

Substances:

Year:  2017        PMID: 28893740      PMCID: PMC5623210          DOI: 10.1136/bcr-2017-220814

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  10 in total

Review 1.  Quality, efficacy and safety of complementary medicines: fashions, facts and the future. Part II: Efficacy and safety.

Authors:  Joanne Barnes
Journal:  Br J Clin Pharmacol       Date:  2003-04       Impact factor: 4.335

Review 2.  Quality, efficacy and safety of complementary medicines: fashions, facts and the future. Part I. Regulation and quality.

Authors:  Joanne Barnes
Journal:  Br J Clin Pharmacol       Date:  2003-03       Impact factor: 4.335

Review 3.  Unexpectedly low pulse oximetry measurements associated with variant hemoglobins: a systematic review.

Authors:  Madeleine Verhovsek; Matthew P A Henderson; Gerard Cox; Hong-yuan Luo; Martin H Steinberg; David H K Chui
Journal:  Am J Hematol       Date:  2010-11       Impact factor: 10.047

4.  Pulse oximetry and genetic hemoglobinopathies.

Authors:  S Mariette; S Leteurtre; A Lambilliotte; F Leclerc
Journal:  Intensive Care Med       Date:  2005-08-27       Impact factor: 17.440

5.  Life-threatening interaction between complementary medicines: cyanide toxicity following ingestion of amygdalin and vitamin C.

Authors:  Jonathan Bromley; Brett G M Hughes; David C S Leong; Nicholas A Buckley
Journal:  Ann Pharmacother       Date:  2005-07-12       Impact factor: 3.154

6.  The role of erythrocytes in cyanide detoxification.

Authors:  D E McMillan; A C Svoboda
Journal:  J Pharmacol Exp Ther       Date:  1982-04       Impact factor: 4.030

7.  Use and expenditure on complementary medicine in England: a population based survey.

Authors:  K J Thomas; J P Nicholl; P Coleman
Journal:  Complement Ther Med       Date:  2001-03       Impact factor: 2.446

8.  Hydroxocobalamin treatment of acute cyanide poisoning from apricot kernels.

Authors:  Davide Cigolini; Giogio Ricci; Massimo Zannoni; Rosalia Codogni; Manuela De Luca; Paola Perfetti; Giampaolo Rocca
Journal:  BMJ Case Rep       Date:  2011-05-24

9.  Acute cyanide toxicity caused by apricot kernel ingestion.

Authors:  J R Suchard; K L Wallace; R D Gerkin
Journal:  Ann Emerg Med       Date:  1998-12       Impact factor: 5.721

10.  The cyanide content of laetrile preparations, apricot, peach and apple seeds.

Authors:  M D Holzbecher; M A Moss; H A Ellenberger
Journal:  J Toxicol Clin Toxicol       Date:  1984
  10 in total
  1 in total

Review 1.  Toxicity of herbal medications suggested as treatment for COVID-19: A narrative review.

Authors:  Michael A DiPietro; Christopher Mondie
Journal:  J Am Coll Emerg Physicians Open       Date:  2021-03-31
  1 in total

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