Literature DB >> 28893007

MRI in Chemotherapy induced Leukoencephalopathy: Report of Two Cases and Radiologist's Perspective.

Geetika Sindhwani1, Manali Arora2, Vishal Dhirenbhai Thakker2, Abhinav Jain3.   

Abstract

Leukoencephalopathy is a progressive white matter disease primarily caused due to myelin damage by a variety of factors. Chemotherapy for oncological treatment is an uncommon but important cause of potentially reversible leukoencephalopathy. In current radiological setting, conventional and diffusion weighted MRI play a significant role in early and accurate detection of this entity. We are hereby presenting MRI evaluation of two cases of methotrexate and 5-fluorouracil induced toxic leukoencephalopathy.

Entities:  

Keywords:  Diffusion weighted imaging; Methotrexate; Neurotoxicity; Toxic encephalopathy

Year:  2017        PMID： 28893007      PMCID： PMC5583911          DOI： 10.7860/JCDR/2017/29164.10248

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN： 0973-709X


  10 in total

Review 1.  Toxic leukoencephalopathy.

Authors:  C M Filley; B K Kleinschmidt-DeMasters
Journal:  N Engl J Med       Date:  2001-08-09       Impact factor: 91.245

2.  Early detection of 5-FU-induced acute leukoencephalopathy on diffusion-weighted MRI.

Authors:  Reiko Akitake; Shin'ichi Miyamoto; Fumiyasu Nakamura; Takahiro Horimatsu; Yasumasa Ezoe; Manabu Muto; Tsutomu Chiba
Journal:  Jpn J Clin Oncol       Date:  2010-10-06       Impact factor: 3.019

Review 3.  The remarkable spectrum of methotrexate toxicities.

Authors:  R J McKendry
Journal:  Rheum Dis Clin North Am       Date:  1997-11       Impact factor: 2.670

4.  Leukoencephalopathy and raised brain lactate from heroin vapor inhalation ("chasing the dragon")

Authors:  A R Kriegstein; D C Shungu; W S Millar; B A Armitage; J C Brust; S Chillrud; J Goldman; T Lynch
Journal:  Neurology       Date:  1999-11-10       Impact factor: 9.910

5.  Acute methotrexate neurotoxicity: findings on diffusion-weighted imaging and correlation with clinical outcome.

Authors:  Nancy Rollins; Naomi Winick; Robert Bash; Timothy Booth
Journal:  AJNR Am J Neuroradiol       Date:  2004 Nov-Dec       Impact factor: 3.825

6.  Methotrexate-induced acute toxic leukoencephalopathy.

Authors:  Parag R Salkade; Teh Aun Lim
Journal:  J Cancer Res Ther       Date:  2012 Apr-Jun       Impact factor: 1.805

Review 7.  Central and peripheral nervous system toxicity of common chemotherapeutic agents.

Authors:  Chrissa Sioka; Athanassios P Kyritsis
Journal:  Cancer Chemother Pharmacol       Date:  2008-11-25       Impact factor: 3.333

8.  Acute toxic leukoencephalopathy: potential for reversibility clinically and on MRI with diffusion-weighted and FLAIR imaging.

Authors:  Alexander M McKinney; Stephen A Kieffer; Rogerich T Paylor; Karen S SantaCruz; Ayse Kendi; Leandro Lucato
Journal:  AJR Am J Roentgenol       Date:  2009-07       Impact factor: 3.959

9.  MRI of non-neoplastic cranial complications of malignant disorders.

Authors:  Banu Yağmurlu; Serap Akyürek; Suat Fitoz; Ahmet Demirkazik
Journal:  Diagn Interv Radiol       Date:  2008-06       Impact factor: 2.630

10.  Diffusion-weighted magnetic resonance imaging in acute reversible toxic leukoencephalopathy: A report of two cases.

Authors:  S Sivasubramanian; Srikant Moorthy; Kp Sreekumar; R Rajesh Kannan
Journal:  Indian J Radiol Imaging       Date:  2010-08
  10 in total
  5 in total

Review 1.  Chemotherapy and the pediatric brain.

Authors:  Chrysanthy Ikonomidou
Journal:  Mol Cell Pediatr       Date:  2018-11-06

Review 2.  Brain tumour post-treatment imaging and treatment-related complications.

Authors:  Alexander T Kessler; Alok A Bhatt
Journal:  Insights Imaging       Date:  2018-11-08

3.  A Role of Microtubules in Oligodendrocyte Differentiation.

Authors:  Bo Yoon Lee; Eun-Mi Hur
Journal:  Int J Mol Sci       Date:  2020-02-05       Impact factor: 5.923

4.  Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits.

Authors:  Jenolyn F Alexander; Alexandre V Seua; Luis D Arroyo; Pradipta R Ray; Andi Wangzhou; Laura Heiβ-Lückemann; Manfred Schedlowski; Theodore J Price; Annemieke Kavelaars; Cobi J Heijnen
Journal:  Theranostics       Date:  2021-01-01       Impact factor: 11.556

5.  Evaluation of toxic effects of chemotherapy in lung malignancies on cerebral white matter using diffusion tensor imaging.

Authors:  Sinem Aydin; Tarik Demir; Haci Mehmet Turk; Dilek Hacer Cesme; Altay Aliyev; Mehmet Ali Gultekin; Temel Fatih Yilmaz; Alpay Alkan
Journal:  Radiol Oncol       Date:  2022-05-04       Impact factor: 4.214
  5 in total

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