OBJECTIVES: Recent studies suggest that intraindividual variability (IIV) of neuropsychological performance may be sensitive to HIV-associated neurologic compromise. IIV may be particularly dependent upon the integrity of frontal-subcortical systems, and therefore may be a meaningful phenotype in HIV. We examined the relationship between change in IIV and white matter integrity among HIV seropositive (HIV+) and HIV seronegative (HIV-) individuals. METHOD: The sample consisted of 38 HIV+ participants and 26 HIV- control participants who underwent neuroimaging and a neuropsychological evaluation at baseline and at 2-year follow-up evaluation. RESULTS: Among HIV+ participants, increases in IIV (greater dispersion) were related to lower fractional anisotropy (FA) values in the anterior thalamic radiations (ATR) and the superior longitudinal fasciculus (SLF). Changes in mean-level global cognitive functioning were not significantly related to white matter integrity. Additionally, there was a significant Group × IIV interaction effect in the SLF demonstrating that the relationship between IIV and white matter integrity was specific to HIV. CONCLUSIONS: Overall, findings suggest that IIV may be more sensitive, relative to mean-level global cognitive functioning, in the detection of neurologic compromise among HIV+ individuals. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
OBJECTIVES: Recent studies suggest that intraindividual variability (IIV) of neuropsychological performance may be sensitive to HIV-associated neurologic compromise. IIV may be particularly dependent upon the integrity of frontal-subcortical systems, and therefore may be a meaningful phenotype in HIV. We examined the relationship between change in IIV and white matter integrity among HIV seropositive (HIV+) and HIV seronegative (HIV-) individuals. METHOD: The sample consisted of 38 HIV+ participants and 26 HIV- control participants who underwent neuroimaging and a neuropsychological evaluation at baseline and at 2-year follow-up evaluation. RESULTS: Among HIV+ participants, increases in IIV (greater dispersion) were related to lower fractional anisotropy (FA) values in the anterior thalamic radiations (ATR) and the superior longitudinal fasciculus (SLF). Changes in mean-level global cognitive functioning were not significantly related to white matter integrity. Additionally, there was a significant Group × IIV interaction effect in the SLF demonstrating that the relationship between IIV and white matter integrity was specific to HIV. CONCLUSIONS: Overall, findings suggest that IIV may be more sensitive, relative to mean-level global cognitive functioning, in the detection of neurologic compromise among HIV+ individuals. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
Authors: Nicholas S Thaler; Philip Sayegh; Alyssa Arentoft; April D Thames; Steven A Castellon; Charlie H Hinkin Journal: Neuropsychology Date: 2015-03-02 Impact factor: 3.295
Authors: C H Hinkin; S A Castellon; R S Durvasula; D J Hardy; M N Lam; K I Mason; D Thrasher; M B Goetz; M Stefaniak Journal: Neurology Date: 2002-12-24 Impact factor: 9.910
Authors: Katherine H Karlsgodt; Theo G M van Erp; Russell A Poldrack; Carrie E Bearden; Keith H Nuechterlein; Tyrone D Cannon Journal: Biol Psychiatry Date: 2007-08-27 Impact factor: 13.382
Authors: Mark L Ettenhofer; Charles H Hinkin; Steven A Castellon; Ramani Durvasula; Jodi Ullman; Mona Lam; Hector Myers; Matthew J Wright; Jessica Foley Journal: Am J Geriatr Psychiatry Date: 2009-04 Impact factor: 4.105
Authors: Robert K Heaton; Donald R Franklin; Ronald J Ellis; J Allen McCutchan; Scott L Letendre; Shannon Leblanc; Stephanie H Corkran; Nichole A Duarte; David B Clifford; Steven P Woods; Ann C Collier; Christina M Marra; Susan Morgello; Monica Rivera Mindt; Michael J Taylor; Thomas D Marcotte; J Hampton Atkinson; Tanya Wolfson; Benjamin B Gelman; Justin C McArthur; David M Simpson; Ian Abramson; Anthony Gamst; Christine Fennema-Notestine; Terry L Jernigan; Joseph Wong; Igor Grant Journal: J Neurovirol Date: 2010-12-21 Impact factor: 2.643
Authors: Joseph M Gullett; Damon G Lamb; Eric Porges; Adam J Woods; Jake Rieke; Paul Thompson; Neda Jahanshad; Talia M Nir; Karen Tashima; Ronald A Cohen Journal: Alcohol Clin Exp Res Date: 2018-07-16 Impact factor: 3.455
Authors: Ariana E Anderson; Jacob D Jones; Nicholas S Thaler; Taylor P Kuhn; Elyse J Singer; Charles H Hinkin Journal: Neuropsychology Date: 2018-09-13 Impact factor: 3.295
Authors: Scott F Sorg; Victoria C Merritt; Alexandra L Clark; Madeleine L Werhane; Kelsey A Holiday; Dawn M Schiehser; Mark Bondi; Lisa Delano-Wood Journal: J Int Neuropsychol Soc Date: 2020-09-24 Impact factor: 2.892
Authors: Shana A Hall; Ryan P Bell; Simon W Davis; Sheri L Towe; Taylor P Ikner; Christina S Meade Journal: Hum Brain Mapp Date: 2021-08-12 Impact factor: 5.038
Authors: Joseph M Gullett; Andrew O'Shea; Damon G Lamb; Eric C Porges; Deirdre M O'Shea; Ofer Pasternak; Ronald A Cohen; Adam J Woods Journal: Neuroimage Date: 2020-06-10 Impact factor: 6.556