| Literature DB >> 28891613 |
Ling Zhou1, Wei Dong1, Yue-de Wang1, Kun Zhou1, Hang-Ying Ma1, Yan Yang1, Huan-Huan Xing1, Min Zhou1, Qiu-Fen Hu1, Yan-Qing Ye1.
Abstract
A new isoindole alkaloid (1), has been isolated from the leaves of Cassia siamea by using various chromatographic techniques. Compound 1 is a new compound, determined as 5-(hydroxymethyl)-2-methyl-6-prenylisoindolin-1-one, and it displayed cytotoxicity against NB4, A549, SHSY5Y, PC3 and MCF7 cell lines with IC₅₀ values of 3.2,4.6,2.8,6.4, 2.5 μmol•L⁻¹, respectively. Copyright© by the Chinese Pharmaceutical Association.Entities:
Keywords: Cassia siamea ; Dai drug ; cytotoxicity ; isoindole alkaloid
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Year: 2016 PMID： 28891613 DOI： 10.4268/cjcmm20160913
Source DB: PubMed Journal: Zhongguo Zhong Yao Za Zhi ISSN： 1001-5302