Zeyuan Fan1, Hanhua Ji1, Yang Li1, Xinwen Jian1, Li Li1, Tao Liu1. 1. Department of Cardiovascular Diseases, Civil Aviation General Hospital, Civil Aviation Clinical Medical College of Peking University, Beijing, China.
Abstract
AIM: To investigate the relationship between monocyte-to-lymphocyte ratio (MLR) and plaque vulnerability assessed by virtual histology intravascular ultrasound in patients with stable angina. METHODS: 133 patients with stable angina were enrolled. RESULTS: MLR was found to be an independent risk factor of thin cap fibrous atheroma (OR: 2.61; p = 0.025). MLR could differentiate thin cap fibrous atheroma with a sensitivity of 73.7% and a specificity of 61.8%. MLR level was positively correlated with the percentage of necrotic core (NC) area at the sites of minimum lumen area and the largest NC area, and positively related to the percentage of NC volume. CONCLUSION: Circulating MLR level has potential in identifying the vulnerable plaques in the setting of stable angina.
AIM: To investigate the relationship between monocyte-to-lymphocyte ratio (MLR) and plaque vulnerability assessed by virtual histology intravascular ultrasound in patients with stable angina. METHODS: 133 patients with stable angina were enrolled. RESULTS: MLR was found to be an independent risk factor of thin cap fibrous atheroma (OR: 2.61; p = 0.025). MLR could differentiate thin cap fibrous atheroma with a sensitivity of 73.7% and a specificity of 61.8%. MLR level was positively correlated with the percentage of necrotic core (NC) area at the sites of minimum lumen area and the largest NC area, and positively related to the percentage of NC volume. CONCLUSION: Circulating MLR level has potential in identifying the vulnerable plaques in the setting of stable angina.
Authors: Ewelina A Dziedzic; Jakub S Gąsior; Agnieszka Tuzimek; Justyna Paleczny; Adam Junka; Marek Dąbrowski; Piotr Jankowski Journal: Int J Mol Sci Date: 2022-08-23 Impact factor: 6.208
Authors: Ewelina A Dziedzic; Jakub S Gąsior; Agnieszka Tuzimek; Marek Dąbrowski; Piotr Jankowski Journal: Nutrients Date: 2022-10-10 Impact factor: 6.706