| Literature DB >> 28891321 |
Jia-Ling Song1,2, Yao Yuan1,2, Ling-Hui Nie3, Bai-Lin Li1,2, Xu-Bing Qin1,2, Yan Li1,2, Jie-Wei Wu1, Sheng-Xiang Qiu1.
Abstract
Two new ent-kaurane diterpenes (1-2), together with five known analogs, were isolated from the stems of Eurya chinensis. The structures of new compounds were established by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. Compound 3 exhibited noticeable anti-inflammatory activity as denoted by inhibiting LPS-induced nitric oxide (NO) production in RAW264.7 cells with an IC50 value of 7.82 μM. Compound 4 showed potent cytotoxic activity against human cancer cell lines NCI-H46, HepG2 and SW480 with IC50 values ranging from 7.45 to 8.54 μM.Entities:
Keywords: Theaceae; anti-inflammatory; cytotoxic activity; diterpene
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Year: 2017 PMID： 28891321 DOI： 10.1080/10286020.2017.1373099
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569