Literature DB >> 28891157

PTEN in the maintenance of genome integrity: From DNA replication to chromosome segregation.

Sheng-Qi Hou1, Meng Ouyang1, Andrew Brandmaier1, Hongbo Hao1, Wen H Shen1.   

Abstract

Faithful DNA replication and accurate chromosome segregation are the key machineries of genetic transmission. Disruption of these processes represents a hallmark of cancer and often results from loss of tumor suppressors. PTEN is an important tumor suppressor that is frequently mutated or deleted in human cancer. Loss of PTEN has been associated with aneuploidy and poor prognosis in cancer patients. In mice, Pten deletion or mutation drives genomic instability and tumor development. PTEN deficiency induces DNA replication stress, confers stress tolerance, and disrupts mitotic spindle architecture, leading to accumulation of structural and numerical chromosome instability. Therefore, PTEN guards the genome by controlling multiple processes of chromosome inheritance. Here, we summarize current understanding of the PTEN function in promoting high-fidelity transmission of genetic information. We also discuss the PTEN pathways of genome maintenance and highlight potential targets for cancer treatment.
© 2017 WILEY Periodicals, Inc.

Entities:  

Keywords:  DNA replication; PTEN; checkpoint; chromosome segregation; genome; mitotic spindle

Mesh：

Substances：

Year:  2017        PMID： 28891157      PMCID： PMC5659364          DOI： 10.1002/bies.201700082

Source DB:  PubMed          Journal:  Bioessays        ISSN： 0265-9247            Impact factor:   4.345


  50 in total

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2.  PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway.

Authors:  H Sun; R Lesche; D M Li; J Liliental; H Zhang; J Gao; N Gavrilova; B Mueller; X Liu; H Wu
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-25       Impact factor: 11.205

3.  Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals.

Authors:  Michelle S Levine; Bjorn Bakker; Bram Boeckx; Julia Moyett; James Lu; Benjamin Vitre; Diana C Spierings; Peter M Lansdorp; Don W Cleveland; Diether Lambrechts; Floris Foijer; Andrew J Holland
Journal:  Dev Cell       Date:  2017-01-26       Impact factor: 12.270

4.  Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

Authors:  Eva Petermann; Manuel Luís Orta; Natalia Issaeva; Niklas Schultz; Thomas Helleday
Journal:  Mol Cell       Date:  2010-02-26       Impact factor: 17.970

5.  Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.

Authors:  Darren J Baker; Fang Jin; Karthik B Jeganathan; Jan M van Deursen
Journal:  Cancer Cell       Date:  2009-12-08       Impact factor: 31.743

6.  High cumulative risks of cancer in patients with PTEN hamartoma tumour syndrome.

Authors:  Virginie Bubien; Françoise Bonnet; Veronique Brouste; Stéphanie Hoppe; Emmanuelle Barouk-Simonet; Albert David; Patrick Edery; Armand Bottani; Valérie Layet; Olivier Caron; Brigitte Gilbert-Dussardier; Capucine Delnatte; Catherine Dugast; Jean-Pierre Fricker; Dominique Bonneau; Nicolas Sevenet; Michel Longy; Frédéric Caux
Journal:  J Med Genet       Date:  2013-01-18       Impact factor: 6.318

7.  PTEN Controls the DNA Replication Process through MCM2 in Response to Replicative Stress.

Authors:  Jiawen Feng; Jing Liang; Jiaju Li; Yunqiao Li; Hui Liang; Xuyang Zhao; Michael A McNutt; Yuxin Yin
Journal:  Cell Rep       Date:  2015-11-05       Impact factor: 9.423

8.  The PTEN-Akt pathway impacts the integrity and composition of mitotic centrosomes.

Authors:  Mary K Leonard; Natasha T Hill; Paula A Bubulya; Madhavi P Kadakia
Journal:  Cell Cycle       Date:  2013-04-09       Impact factor: 4.534

9.  PTEN regulates DNA replication progression and stalled fork recovery.

Authors:  Jinxue He; Xi Kang; Yuxin Yin; K S Clifford Chao; Wen H Shen
Journal:  Nat Commun       Date:  2015-07-09       Impact factor: 14.919

10.  BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer.

Authors:  Robbyn L Weaver; Jazeel F Limzerwala; Ryan M Naylor; Karthik B Jeganathan; Darren J Baker; Jan M van Deursen
Journal:  Elife       Date:  2016-08-16       Impact factor: 8.140
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  29 in total

1.  PTEN modulates gene transcription by redistributing genome-wide RNA polymerase II occupancy.

Authors:  Ata Abbas; Roshan Padmanabhan; Todd Romigh; Charis Eng
Journal:  Hum Mol Genet       Date:  2019-09-01       Impact factor: 6.150

2.  PTEN as a Guardian of the Genome: Pathways and Targets.

Authors:  Xinyi Fan; Jeffrey Kraynak; Jonathan P S Knisely; Silvia C Formenti; Wen H Shen
Journal:  Cold Spring Harb Perspect Med       Date:  2020-09-01       Impact factor: 6.915

Review 3.  The biochemical and clinical implications of phosphatase and tensin homolog deleted on chromosome ten in different cancers.

Authors:  Qinyi Wang; Junmin Wang; Hongjiao Xiang; Peilun Ding; Tao Wu; Guang Ji
Journal:  Am J Cancer Res       Date:  2021-12-15       Impact factor: 6.166

4.  Exome sequencing reveals a distinct somatic genomic landscape in breast cancer from women with germline PTEN variants.

Authors:  Takae Brewer; Lamis Yehia; Peter Bazeley; Charis Eng
Journal:  Am J Hum Genet       Date:  2022-08-04       Impact factor: 11.043

5.  Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas.

Authors:  Eleonora Sementino; Craig W Menges; Yuwaraj Kadariya; Suraj Peri; Jinfei Xu; Zemin Liu; Richard G Wilkes; Kathy Q Cai; Frank J Rauscher; Andres J Klein-Szanto; Joseph R Testa
Journal:  J Cell Physiol       Date:  2018-06-15       Impact factor: 6.384

Review 6.  PTEN in Chromatin Remodeling.

Authors:  Jingyi Yang; Yuxin Yin
Journal:  Cold Spring Harb Perspect Med       Date:  2020-02-03       Impact factor: 6.915

7.  PTEN mutations predict benefit from tumor treating fields (TTFields) therapy in patients with recurrent glioblastoma.

Authors:  Antonio Dono; Sonali Mitra; Mauli Shah; Takeshi Takayasu; Jay-Jiguang Zhu; Nitin Tandon; Chirag B Patel; Yoshua Esquenazi; Leomar Y Ballester
Journal:  J Neurooncol       Date:  2021-04-21       Impact factor: 4.130

8.  Genomic alterations predictive of response to radiosurgery in recurrent IDH-WT glioblastoma.

Authors:  Antonio Dono; Mark Amsbaugh; Magda Martir; Richard H Smilie; Roy F Riascos; Jay-Jiguang Zhu; Sigmund Hsu; Dong H Kim; Nitin Tandon; Leomar Y Ballester; Angel I Blanco; Yoshua Esquenazi
Journal:  J Neurooncol       Date:  2021-01-25       Impact factor: 4.130

9.  Distinct subtypes of genomic PTEN deletion size influence the landscape of aneuploidy and outcome in prostate cancer.

Authors:  Thiago Vidotto; Daniel Guimarães Tiezzi; Jeremy A Squire
Journal:  Mol Cytogenet       Date:  2018-01-03       Impact factor: 2.009

Review 10.  Permeabilizing Cell Membranes with Electric Fields.

Authors:  Alondra A Aguilar; Michelle C Ho; Edwin Chang; Kristen W Carlson; Arutselvan Natarajan; Tal Marciano; Ze'ev Bomzon; Chirag B Patel
Journal:  Cancers (Basel)       Date:  2021-05-10       Impact factor: 6.639
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