Malihe Nourollahpour Shiadeh1,2, Seyed Mohammad Riahi3,4, Ishag Adam5, Vafa Saber6, Zahra Behboodi Moghadam1, Bahram Armon7, Adel Spotin8, Hajar Nazari Kangavari4, Ali Rostami9. 1. a Department of Midwifery and Reproductive Health , Nursing and Midwifery School, Tehran University of Medical Sciences , Tehran , Iran. 2. b Department of Midwifery and Reproductive Health , Nursing and Midwifery School, Mazandaran University of Medical Sciences , Sari , Iran. 3. c Faculty of Health , Birjand University of Medical Sciences , Birjand , Iran. 4. d Department of Epidemiology , School of Public Health, Shahid Beheshti University of Medical Sciences , Tehran , Iran. 5. e Faculty of Medicine , University of Khartoum , Khartoum , Sudan. 6. f Department of Parasitology and Mycology , School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran. 7. g Psychosis Research Center, University of Social Welfare and Rehabilitation Sciences , Tehran , Iran. 8. h Immunology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran. 9. i Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences , Babol , Iran.
Abstract
OBJECTIVE: Helicobacter pylori is associated with many pregnancy adverse effects such as preeclampsia (PE). We performed this systematic review and meta-analysis study to assess the possible association between H. pylori infection and PE and this is the first meta-analysis to clarify this issue. METHODS: PubMed, ISI (Web of Science), SCOPUS, and Google Scholar databases were searched (up to April 2017) to identify the relevant studies. The Meta-analysis of Observational Studies in Epidemiology and Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines were used to do this study. Pooled odds ratio (OR) and 95% confidence intervals (CI) were estimated using a random-effects meta-analysis model. Heterogeneity was assessed with the χ2-based Q-test and I2 statistic. RESULTS: A total of eight studies including 889 participants (460 preeclamptic women and 429 controls) met the eligibility criteria. A positive association was found between H. pylori infection and PE (OR: 3.35; 95% CI: 2.21-5.10). Heterogeneity was acceptable (χ2 = 13.39; I2 = 47.7, 95% CI: 0-77). In subgroup analysis, cytotoxin-associated antigen A seropositivity was a substantial risk factor for PE when immunoblotting methods (OR: 11.12; 95% CI: 5.34-23.16; χ2 = 6.42; I2 = 53.3, 95% CI: 0-85) were used, whereas it was not potential risk factor for PE when ELISA was used as a detecting method (OR: 1.11; 95% CI: 0.6-2.06; χ2 = 1.83; I2 = 0, 95% CI: 0-90). CONCLUSIONS: This study indicated that women with H. pylori infection, especially those infected with Cag A positive strains are more likely to have PE compared with the uninfected women.
OBJECTIVE:Helicobacter pylori is associated with many pregnancy adverse effects such as preeclampsia (PE). We performed this systematic review and meta-analysis study to assess the possible association between H. pyloriinfection and PE and this is the first meta-analysis to clarify this issue. METHODS: PubMed, ISI (Web of Science), SCOPUS, and Google Scholar databases were searched (up to April 2017) to identify the relevant studies. The Meta-analysis of Observational Studies in Epidemiology and Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines were used to do this study. Pooled odds ratio (OR) and 95% confidence intervals (CI) were estimated using a random-effects meta-analysis model. Heterogeneity was assessed with the χ2-based Q-test and I2 statistic. RESULTS: A total of eight studies including 889 participants (460 preeclamptic women and 429 controls) met the eligibility criteria. A positive association was found between H. pyloriinfection and PE (OR: 3.35; 95% CI: 2.21-5.10). Heterogeneity was acceptable (χ2 = 13.39; I2 = 47.7, 95% CI: 0-77). In subgroup analysis, cytotoxin-associated antigen A seropositivity was a substantial risk factor for PE when immunoblotting methods (OR: 11.12; 95% CI: 5.34-23.16; χ2 = 6.42; I2 = 53.3, 95% CI: 0-85) were used, whereas it was not potential risk factor for PE when ELISA was used as a detecting method (OR: 1.11; 95% CI: 0.6-2.06; χ2 = 1.83; I2 = 0, 95% CI: 0-90). CONCLUSIONS: This study indicated that women with H. pyloriinfection, especially those infected with Cag A positive strains are more likely to have PE compared with the uninfected women.
Entities:
Keywords:
Helicobacter pylori; cytotoxin-associated antigen A; preeclampsia; pregnant women
Authors: Eliza C Miller; Marisa Gallo; Erin R Kulick; Alexander M Friedman; Mitchell S V Elkind; Amelia K Boehme Journal: Stroke Date: 2018-05 Impact factor: 7.914