Literature DB >> 28888831

Steryl ester synthesis, storage and hydrolysis: A contribution to sterol homeostasis.

Martina Korber1, Isabella Klein1, Günther Daum2.   

Abstract

Sterols are essential lipids of all eukaryotic cells, appearing either as free sterols or steryl esters. Besides other regulatory mechanisms, esterification of sterols and hydrolysis of steryl esters serve to buffer both an excess and a lack of free sterols. In this review, the esterification process, the storage of steryl esters and their mobilization will be described. Several model organisms are discussed but the focus was set on mammals and the yeast Saccharomyces cerevisiae. The contribution of imbalanced cholesterol homeostasis to several human diseases, namely Wolman disease, cholesteryl ester storage disease, atherosclerosis and Alzheimer's disease, Niemann-Pick type C and Tangier disease is described.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Lipid droplet; Sterol homeostasis; Steryl ester hydrolase; Steryl ester synthase

Mesh：

Substances：

Year:  2017        PMID： 28888831     DOI： 10.1016/j.bbalip.2017.09.002

Source DB:  PubMed          Journal:  Biochim Biophys Acta Mol Cell Biol Lipids        ISSN： 1388-1981            Impact factor:   4.698


  12 in total

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8.  Identification and Characterization of Sterol Acyltransferases Responsible for Steryl Ester Biosynthesis in Tomato.

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