D Coric1,2, L J Balk1,2, B M J Uitdehaag1, A Petzold1,2,3,4,5. 1. Department of Neurology, VU University Medical Center Amsterdam, Amsterdam, the Netherlands. 2. Expertise-Center Neuro-Ophthalmology, VU University Medical Center Amsterdam, Amsterdam, the Netherlands. 3. Moorfields Eye Hospital, London, UK. 4. The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. 5. UCL, Institute of Neurology, London, UK.
Abstract
BACKGROUND AND PURPOSE: Multiple sclerosis-associated optic neuritis (MSON) causes atrophy of the inner retinal layers, which can be quantified by optical coherence tomography. It has been suggested that the inter-eye percentage difference (IEPD) of atrophy may be of diagnostic value in MSON. METHODS: This was a prospective, cross-sectional study in patients with multiple sclerosis and healthy controls (HCs). Spectral-domain optical coherence tomography of both eyes was performed, followed by automated retinal layer segmentation of the peri-papillary retinal nerve fibre layer (pRNFL) and macular ganglion cell and inner plexiform layer (mGCIPL). Receiver operator characteristics curves were plotted and the area under the curve was calculated for group comparisons of the IEPD of the pRNFL and mGCIPL. RESULTS: There were 39 patients with bilateral MSON, 62 patients with unilateral MSON, 106 patients without MSON and 63 HCs. Diagnostic accuracy (area under the curve) of the IEPD was 0.73-0.86 for the pRNFL and 0.75-0.94 for the mGCIPL. The diagnostic sensitivity of the mGCIPL IEPD was 70% with a specificity of 97% for distinguishing unilateral MSON from HCs. For the comparison of bilateral MSON with HCs, sensitivity was 86% with a specificity of 97%. CONCLUSIONS: The IEPD of the pRNFL, and more particularly the IEPD of the mGCIPL, is a useful diagnostic measure for MSON. The IEPD is a dimensionless unit and may therefore contribute to overcome device and proprietary segmentation algorithm limitations.
BACKGROUND AND PURPOSE:Multiple sclerosis-associated optic neuritis (MSON) causes atrophy of the inner retinal layers, which can be quantified by optical coherence tomography. It has been suggested that the inter-eye percentage difference (IEPD) of atrophy may be of diagnostic value in MSON. METHODS: This was a prospective, cross-sectional study in patients with multiple sclerosis and healthy controls (HCs). Spectral-domain optical coherence tomography of both eyes was performed, followed by automated retinal layer segmentation of the peri-papillary retinal nerve fibre layer (pRNFL) and macular ganglion cell and inner plexiform layer (mGCIPL). Receiver operator characteristics curves were plotted and the area under the curve was calculated for group comparisons of the IEPD of the pRNFL and mGCIPL. RESULTS: There were 39 patients with bilateral MSON, 62 patients with unilateral MSON, 106 patients without MSON and 63 HCs. Diagnostic accuracy (area under the curve) of the IEPD was 0.73-0.86 for the pRNFL and 0.75-0.94 for the mGCIPL. The diagnostic sensitivity of the mGCIPL IEPD was 70% with a specificity of 97% for distinguishing unilateral MSON from HCs. For the comparison of bilateral MSON with HCs, sensitivity was 86% with a specificity of 97%. CONCLUSIONS: The IEPD of the pRNFL, and more particularly the IEPD of the mGCIPL, is a useful diagnostic measure for MSON. The IEPD is a dimensionless unit and may therefore contribute to overcome device and proprietary segmentation algorithm limitations.
Authors: Rachel C Kenney; Mengling Liu; Lisena Hasanaj; Binu Joseph; Abdullah Abu Al-Hassan; Lisanne J Balk; Raed Behbehani; Alexander Brandt; Peter A Calabresi; Elliot Frohman; Teresa C Frohman; Joachim Havla; Bernhard Hemmer; Hong Jiang; Benjamin Knier; Thomas Korn; Letizia Leocani; Elena Hernandez Martinez-Lapiscina; Athina Papadopoulou; Friedemann Paul; Axel Petzold; Marco Pisa; Pablo Villoslada; Hanna Zimmermann; Lorna E Thorpe; Hiroshi Ishikawa; Joel S Schuman; Gadi Wollstein; Yu Chen; Shiv Saidha; Steven Galetta; Laura J Balcer Journal: Neurology Date: 2022-06-28 Impact factor: 11.800
Authors: Laura J Balcer; Lisanne J Balk; Alexander U Brandt; Peter A Calabresi; Elena H Martinez-Lapiscina; Rachel C Nolan; Friedemann Paul; Axel Petzold; Shiv Saidha Journal: J Neuroophthalmol Date: 2018-12 Impact factor: 3.042
Authors: Marta Para-Prieto; Raul Martin; Sara Crespo; Laura Mena-Garcia; Andres Valisena; Lisandro Cordero; Gloria Gonzalez Fernandez; Juan F Arenillas; Nieves Tellez; Jose Carlos Pastor Journal: Clin Ophthalmol Date: 2021-05-14
Authors: Axel Petzold; Philipp Albrecht; Laura Balcer; Erik Bekkers; Alexander U Brandt; Peter A Calabresi; Orla Galvin Deborah; Jennifer S Graves; Ari Green; Pearse A Keane; Jenny A Nij Bijvank; Josemir W Sander; Friedemann Paul; Shiv Saidha; Pablo Villoslada; Siegfried K Wagner; E Ann Yeh Journal: Ann Clin Transl Neurol Date: 2021-05-19 Impact factor: 4.511