Antje Fahrig1, T Koch2, M Lenhart3, P Rieckmann4, R Fietkau5, Luitpold Distel5, B Schuster5. 1. Klinik und Praxis für Radioonkologie und Strahlentherapie, Klinikum Bamberg, Sozialstiftung Bamberg, Buger Straße 80, 96049, Bamberg, Germany. antje.fahrig@sozialstiftung-bamberg.de. 2. Klinik und Praxis für Radioonkologie und Strahlentherapie, Klinikum Bamberg, Sozialstiftung Bamberg, Buger Straße 80, 96049, Bamberg, Germany. 3. Klinik für Diagnostische Radiologie, Interventionelle Radiologie und Neuroradiologie, Klinikum Bamberg, Sozialstiftung Bamberg, Buger Straße 80, 96049, Bamberg, Germany. 4. Neurologische Klinik, Klinikum Bamberg, Sozialstiftung Bamberg, Buger Straße 80, 96049, Bamberg, Germany. 5. Strahlenklinik, Universitätsklinikum Erlangen, Universitätsstraße 27, 91054, Erlangen, Germany.
Abstract
BACKGROUND: In general, late side effects after salvage radiotherapy (RT) for prostate cancer are below 10%. Patients with impaired DNA repair ability and genetic instability can have significantly increased reactions after RT. CASE, CLINICAL FOLLOW-UP, AND EXAMINATION: We present a patient who experienced severe side effects after additive RT for prostate cancer and died from the complications 25 months after RT. Imaging (MR) is shown as well as three-color fluorescence in situ hybridization. The blood sample testing revealed that radiosensitivity was increased by 35-55%. We undertook a review of the literature to give an overview over the tests established that are currently considered useful. CONCLUSION: This case highlights that the identification of patients with increased radiosensitivity is an important task in radiation protection. Groups of patients who should be screened have to be found and corresponding research facilities have to be set up.
BACKGROUND: In general, late side effects after salvage radiotherapy (RT) for prostate cancer are below 10%. Patients with impaired DNA repair ability and genetic instability can have significantly increased reactions after RT. CASE, CLINICAL FOLLOW-UP, AND EXAMINATION: We present a patient who experienced severe side effects after additive RT for prostate cancer and died from the complications 25 months after RT. Imaging (MR) is shown as well as three-color fluorescence in situ hybridization. The blood sample testing revealed that radiosensitivity was increased by 35-55%. We undertook a review of the literature to give an overview over the tests established that are currently considered useful. CONCLUSION: This case highlights that the identification of patients with increased radiosensitivity is an important task in radiation protection. Groups of patients who should be screened have to be found and corresponding research facilities have to be set up.
Entities:
Keywords:
DNA repair; Fluorescence in situ hybridization; Radiation protection; Radiation toxicity; Radiosensitivity
Authors: Hans Strasser; Gerhard G Grabenbauer; Carl N Sprung; Rolf Sauer; Luitpold V R Distel Journal: Strahlenther Onkol Date: 2007-08 Impact factor: 3.621
Authors: Bregje van Oorschot; Suzanne E Hovingh; Perry D Moerland; Jan Paul Medema; Lukas J A Stalpers; Harry Vrieling; Nicolaas A P Franken Journal: Int J Radiat Oncol Biol Phys Date: 2014-01-08 Impact factor: 7.038