| Literature DB >> 28887321 |
Xiang-Song Wu1,2,3, Fang Wang4, Huai-Feng Li1,2,3, Yun-Ping Hu1,2,3, Lin Jiang1,2,3, Fei Zhang1,2,3, Mao-Lan Li1,2,3, Xu-An Wang1,2,3, Yun-Peng Jin1,2,3, Yi-Jian Zhang1,2,3, Wei Lu1,2,3, Wen-Guang Wu1,2,3, Yi-Jun Shu1,2,3, Hao Weng1,2,3, Yang Cao1,2,3, Run-Fa Bao1,2,3, Hai-Bin Liang1,2,3, Zheng Wang1,2,3, Yi-Chi Zhang1,2,3, Wei Gong1,2,3, Lei Zheng5, Shu-Han Sun6, Ying-Bin Liu7,2,3.
Abstract
Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA-PAGBC competitively binds to the tumour suppressive microRNAs miR-133b and miR-511. This competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA-PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.Entities:
Keywords: zzm321990PAGBCzzm321990; ceRNA; gallbladder cancer; lncRNA; prognosis
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Year: 2017 PMID： 28887321 PMCID： PMC5623869 DOI： 10.15252/embr.201744147
Source DB: PubMed Journal: EMBO Rep ISSN： 1469-221X Impact factor: 9.071