OBJECTIVE: To determine the success and feasibility of surgically correcting residual curvature after intralesional collagenase clostridium histolyticum (CCH) for the treatment of Peyronie disease (PD). METHODS: We performed a retrospective analysis of patients who had intralesional CCH treatment for PD and who subsequently underwent penile plication (PP), plaque incision and grafting (PIG), or inflatable penile prosthesis (IPP) placement. RESULTS: Ten men who underwent PP, PIG, or IPP for the treatment of residual curvature after intralesional CCH were identified. Six patients underwent PP; 1 patient underwent PIG; and 3 patients underwent IPP with ancillary straightening maneuvers. The mean time from the last CCH injection to surgical correction was 150.9 days, or 5 months. The mean pre-CCH curvature was 67 degrees and the mean post-CCH curvature was 51 degrees. Eight of 10 patients had no residual curvature after surgical treatment. The mean postprocedure curvature was 4.5 degrees. The mean operative time was 72.1 minutes. The mean estimated blood loss was 20 mL. Increased fibrosis with increased surgical difficulty was noted in 3 (all <6 months post CCH treatment) of 10 patients. No postoperative complications were noted. CONCLUSION: The surgical treatment of PD after intralesional CCH is safe and effective. If surgery is considered, this should be performed at least 6 months after the last CCH injection, given the potential for an increased inflammatory reaction in this area.
OBJECTIVE: To determine the success and feasibility of surgically correcting residual curvature after intralesional collagenase clostridium histolyticum (CCH) for the treatment of Peyronie disease (PD). METHODS: We performed a retrospective analysis of patients who had intralesional CCH treatment for PD and who subsequently underwent penile plication (PP), plaque incision and grafting (PIG), or inflatable penile prosthesis (IPP) placement. RESULTS: Ten men who underwent PP, PIG, or IPP for the treatment of residual curvature after intralesional CCH were identified. Six patients underwent PP; 1 patient underwent PIG; and 3 patients underwent IPP with ancillary straightening maneuvers. The mean time from the last CCH injection to surgical correction was 150.9 days, or 5 months. The mean pre-CCH curvature was 67 degrees and the mean post-CCH curvature was 51 degrees. Eight of 10 patients had no residual curvature after surgical treatment. The mean postprocedure curvature was 4.5 degrees. The mean operative time was 72.1 minutes. The mean estimated blood loss was 20 mL. Increased fibrosis with increased surgical difficulty was noted in 3 (all <6 months post CCH treatment) of 10 patients. No postoperative complications were noted. CONCLUSION: The surgical treatment of PD after intralesional CCH is safe and effective. If surgery is considered, this should be performed at least 6 months after the last CCH injection, given the potential for an increased inflammatory reaction in this area.
Authors: Andrea Cocci; David Ralph; Rados Djinovic; Georgios Hatzichristodoulou; Girolamo Morelli; Andrea Salonia; Paolo Capogrosso; Andrea Romano; Gianmartin Cito; Fabrizio Di Maida; Esaú Fernández-Pascual; Javier Romero-Otero; Paulo Egydio; Marco Falcone; Mirko Preto; Giovanni Chiriacò; Jack Beck; Maarten Albersen; Suks Minhas; Giovanni Cacciamani; Juan Ignacio Martinez Salamanca; Nicola Mondani; Andrea Minervini; Giorgio Ivan Russo Journal: Sci Rep Date: 2021-01-08 Impact factor: 4.379
Authors: Daniar Osmonov; Ahmed Ragheb; Sam Ward; Gideon Blecher; Marco Falcone; Armin Soave; Roland Dahlem; Koenraad van Renterghem; Nim Christopher; Georgios Hatzichristodoulou; Mirko Preto; Giulio Garaffa; Maarten Albersen; Carlo Bettocchi; Giovanni Corona; Yacov Reisman Journal: Sex Med Date: 2021-11-22 Impact factor: 2.491
Authors: Denis V Krakhotkin; David J Ralph; Gideon A Blecher; Volodymyr A Chernylovskyi; Francesco Greco; Evgeny E Bakurov; Ruslan A Bugaev Journal: Asian J Androl Date: 2021 Mar-Apr Impact factor: 3.285