Annelies E Veldwijk-Rouwenhorst1, Martin Smalbrugge2, Roland Wetzels3, Hans Bor4, Sytse U Zuidema5, Raymond T C M Koopmans6, Debby L Gerritsen3. 1. Department of Primary and Community Care, Center for Family Medicine, Geriatric Care and Public Health, Radboud University Medical Center, Nijmegen, The Netherlands; Radboudumc Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: annelies.veldwijk-rouwenhorst@radboudumc.nl. 2. Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands. 3. Department of Primary and Community Care, Center for Family Medicine, Geriatric Care and Public Health, Radboud University Medical Center, Nijmegen, The Netherlands; Radboudumc Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands. 4. Department of Primary and Community Care, Center for Family Medicine, Geriatric Care and Public Health, Radboud University Medical Center, Nijmegen, The Netherlands. 5. Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 6. Department of Primary and Community Care, Center for Family Medicine, Geriatric Care and Public Health, Radboud University Medical Center, Nijmegen, The Netherlands; Radboudumc Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands; De Waalboog, Center for Specialized Geriatric Care "Joachim en Anna", Nijmegen, The Netherlands.
Abstract
OBJECTIVE: Although many nursing home residents with dementia show agitation, hardly any literature is published about very frequent agitation. The WAALBED-III study focuses on the 2-week prevalence and correlates of very frequent agitation in these residents. DESIGN: Cross-sectional study using combined data of four studies. SETTING: One hundred nineteen dementia special care units in twenty-six nursing homes in The Netherlands. PARTICIPANTS: Two thousand seventy-four residents with dementia. MEASUREMENTS: We operationally defined very frequent agitation as having a score of 6 (several times a day) or 7 (several times an hour) on at least five items of the Cohen Mansfield Agitation Inventory (CMAI) combined with a CMAI total score above the 90th percentile. To assess the association of demographic and behavioral characteristics with very frequent agitation, we performed a multivariate multilevel logistic regression analysis. RESULTS: The 2-week prevalence of very frequent agitation was 7.4% (95% CI: 6.374-8.634). Correlates for very frequent agitation were age (OR: 0.967, 95% CI: 0.942-0.992), dementia severity (GDS 6 = OR: 3.636, 95% CI: 1.929-6.875; GDS 7 = OR: 2.951, 95% CI: 1.321-6.588), delusions (OR: 2.480, 95% CI: 1.555-3.956), anxiety (OR: 1.904, 95% CI: 1.259-2.881), euphoria (OR: 3.712, 95% CI: 2.171-6.337) and irritability (OR: 4.411, 95% CI: 2.854-6.816). CONCLUSIONS: To our knowledge, this study is the first to report prevalence data and correlates about nursing home residents with very frequent agitation. We found several correlated factors for very frequent agitation. Still, further research is needed for a better understanding of the behavior of this group, and to identify good treatment options.
OBJECTIVE: Although many nursing home residents with dementia show agitation, hardly any literature is published about very frequent agitation. The WAALBED-III study focuses on the 2-week prevalence and correlates of very frequent agitation in these residents. DESIGN: Cross-sectional study using combined data of four studies. SETTING: One hundred nineteen dementia special care units in twenty-six nursing homes in The Netherlands. PARTICIPANTS: Two thousand seventy-four residents with dementia. MEASUREMENTS: We operationally defined very frequent agitation as having a score of 6 (several times a day) or 7 (several times an hour) on at least five items of the Cohen Mansfield Agitation Inventory (CMAI) combined with a CMAI total score above the 90th percentile. To assess the association of demographic and behavioral characteristics with very frequent agitation, we performed a multivariate multilevel logistic regression analysis. RESULTS: The 2-week prevalence of very frequent agitation was 7.4% (95% CI: 6.374-8.634). Correlates for very frequent agitation were age (OR: 0.967, 95% CI: 0.942-0.992), dementia severity (GDS 6 = OR: 3.636, 95% CI: 1.929-6.875; GDS 7 = OR: 2.951, 95% CI: 1.321-6.588), delusions (OR: 2.480, 95% CI: 1.555-3.956), anxiety (OR: 1.904, 95% CI: 1.259-2.881), euphoria (OR: 3.712, 95% CI: 2.171-6.337) and irritability (OR: 4.411, 95% CI: 2.854-6.816). CONCLUSIONS: To our knowledge, this study is the first to report prevalence data and correlates about nursing home residents with very frequent agitation. We found several correlated factors for very frequent agitation. Still, further research is needed for a better understanding of the behavior of this group, and to identify good treatment options.
Authors: Jiamin Du; Sarah Janus; Brenda Voorthuis; Jeannette van Manen; Wilco Achterberg; Martin Smalbrugge; Sandra Zwijsen; Debby Gerritsen; Raymond Koopmans; Sytse Zuidema Journal: Int J Geriatr Psychiatry Date: 2022-03-04 Impact factor: 3.850
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