| Literature DB >> 2888661 |
Abstract
Dependence on the potent narcotic agent heroin in rats was produced by the implication of double-coated pellets. Chronic administration of this drug induced significant alterations in dynorphin B and [Met5]enkephalin-Arg6-Gly7-Leu8 (ME-RGL) levels in discrete areas of the rat brain. The level of the latter increased by 53.6% in the substantia nigra while the levels of dynorphin B increased in the globus pallidus and ventral tegmental area (188.0 and 41.8%, respectively).Entities:
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Year: 1987 PMID： 2888661 DOI： 10.1016/0014-2999(87)90506-1
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432