Geoffrey Loh1, Ilya Ryaboy2, Andrew Skabelund1, Alicia French3. 1. Pulmonary/Critical Care, San Antonio Military Medical Center, Fort Sam Houston, Texas. 2. Internal Medicine, San Antonio Military Medical Center, Fort Sam Houston, Texas. 3. Clinical Nurse Coordinator for Tri-Services Cystic Fibrosis Center at San Antonio Military Medical Center, Fort Sam Houston, Texas.
Abstract
INTRODUCTION: Acute pulmonary exacerbations of cystic fibrosis (APECF) are a leading cause of morbidity and mortality among patients with cystic fibrosis (CF). APECF require frequent administration of antibiotics and subsequently lead to development of resistant organisms. OBJECTIVES: The aim of this study was to identify inflammatory markers that may be help identify need for antibiotics and exacerbation as well as predict risk of exacerbations. METHODS: A total of 17 patients were enrolled, and baseline erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and procalcitonin levels were obtained in addition to obtaining these levels during admissions for APECF. RESULTS: A total of 28 APECF were recorded. ESR and CRP significantly increased during exacerbation (P < .01 for both). Procalcitonin did not increase during exacerbations. Baseline elevations in ESR and CRP increased risk of an exacerbation (RR = 2.3 and 4.5, respectively). CONCLUSIONS: ESR and CRP are useful markers for CF exacerbations, as levels rise with exacerbations. Baseline elevations in ESR and CRP were noted to show an increased risk for CF exacerbations. Procalcitonin, in contrast, is not a useful inflammatory marker.
INTRODUCTION: Acute pulmonary exacerbations of cystic fibrosis (APECF) are a leading cause of morbidity and mortality among patients with cystic fibrosis (CF). APECF require frequent administration of antibiotics and subsequently lead to development of resistant organisms. OBJECTIVES: The aim of this study was to identify inflammatory markers that may be help identify need for antibiotics and exacerbation as well as predict risk of exacerbations. METHODS: A total of 17 patients were enrolled, and baseline erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and procalcitonin levels were obtained in addition to obtaining these levels during admissions for APECF. RESULTS: A total of 28 APECF were recorded. ESR and CRP significantly increased during exacerbation (P < .01 for both). Procalcitonin did not increase during exacerbations. Baseline elevations in ESR and CRP increased risk of an exacerbation (RR = 2.3 and 4.5, respectively). CONCLUSIONS: ESR and CRP are useful markers for CF exacerbations, as levels rise with exacerbations. Baseline elevations in ESR and CRP were noted to show an increased risk for CF exacerbations. Procalcitonin, in contrast, is not a useful inflammatory marker.
Authors: D R VanDevanter; S L Heltshe; M Skalland; N E West; D B Sanders; C H Goss; P A Flume Journal: J Cyst Fibros Date: 2021-12-18 Impact factor: 5.527
Authors: Kristina L Bailey; Peter J Murphy; Olena K Lineberry; Matthew R Haack; John D Dickinson; Andre C Kalil Journal: J Investig Med Date: 2020-01-21 Impact factor: 2.895
Authors: Katherine B Hisert; Timothy P Birkland; Kelly Q Schoenfelt; Matthew E Long; Brenda Grogan; Suzanne Carter; W Conrad Liles; Edward F McKone; Lev Becker; Anne M Manicone; Sina A Gharib Journal: Front Pharmacol Date: 2020-08-13 Impact factor: 5.810