Bénédicte Clin1,2,3, Isabelle Thaon4,5, Mathilde Boulanger1,2,3, Patrick Brochard6,7,8, Soizick Chamming's9, Antoine Gislard10, Aude Lacourt6,7,8, Amandine Luc4,5, Guy Ogier11, Christophe Paris4,5, Jean-Claude Pairon9,12,13,14. 1. INSERM U1086 « ANTICIPE », Caen, France. 2. CHU Caen, Service de santé au travail et pathologie professionnelle, Caen, France. 3. Université de Caen Normandie, Caen, France. 4. EA7298 INGRES, Nancy, France. 5. CHRU Nancy, Nancy, France. 6. INSERM U1219, Bordeaux Population Health, EPICENE, Univ. Bordeaux, Bordeaux, France. 7. Univ. Bordeaux, ISPED, INSERM U1219, Bordeaux Population Health, Bordeaux, France. 8. CHU Bordeaux, Bordeaux, France. 9. Institut Interuniversitaire de Médecine du Travail de Paris-Ile de France, Créteil, France. 10. CHU Rouen, Service des maladies professionnelles, Rouen, France. 11. ERSM Rhône-Alpes, Regional security insurance, Lyon, France. 12. Centre Hospitalier Intercommunal Créteil, DHU A-TVB, Service de pneumologie et pathologie professionnelle, Créteil, France. 13. Institut Santé-Travail Paris-Est, Université Paris-Est Créteil, Faculté de Médecine, Créteil, France. 14. INSERM U955, Equipe 4, Créteil, France.
Abstract
BACKGROUND: Our study aimed at analyzing incidence and mortality from esophageal cancer within a cohort of workers with previous occupational asbestos exposure (ARDCo Program). METHODS: A 10-year follow-up study was conducted in the 14 515 male subjects included in this program between October 2003 and December 2005. Follow-up began when exposure stopped. Asbestos exposure was analyzed by industrial hygienists using data from a standardized questionnaire. The Cox model was used, with age as the time axis variable adjusted for smoking, time since first exposure (TSFE) and cumulative exposure index (CEI) of exposure to asbestos. RESULTS: We reported a significant dose-response relationship between CEI of exposure to asbestos and esophageal cancer, in both incidence (hazard ratio [HR] 1.26, 95% confidence interval [CI] 1.00-1.58), and mortality (HR 1.40, [95%CI 1.12-1.75]). CONCLUSIONS: This large-scale study suggests the existence of a relationship between asbestos exposure and cancer of the esophagus.
BACKGROUND: Our study aimed at analyzing incidence and mortality from esophageal cancer within a cohort of workers with previous occupational asbestos exposure (ARDCo Program). METHODS: A 10-year follow-up study was conducted in the 14 515 male subjects included in this program between October 2003 and December 2005. Follow-up began when exposure stopped. Asbestos exposure was analyzed by industrial hygienists using data from a standardized questionnaire. The Cox model was used, with age as the time axis variable adjusted for smoking, time since first exposure (TSFE) and cumulative exposure index (CEI) of exposure to asbestos. RESULTS: We reported a significant dose-response relationship between CEI of exposure to asbestos and esophageal cancer, in both incidence (hazard ratio [HR] 1.26, 95% confidence interval [CI] 1.00-1.58), and mortality (HR 1.40, [95%CI 1.12-1.75]). CONCLUSIONS: This large-scale study suggests the existence of a relationship between asbestos exposure and cancer of the esophagus.