Vaishali A Patel1,2, Paul St Romain3, Juan Sanchez4, Deborah A Fisher3,5,6, Ryan D Schulteis7,8. 1. Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA. vaishali.patel@emory.edu. 2. Division of Gastroenterology, Department of Medicine, Emory University Hospital, 558 Rock Springs Rd NE, Atlanta, GA, 30324, USA. vaishali.patel@emory.edu. 3. Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA. 4. Department of Internal Medicine, Duke University Medical Center, Durham, NC, USA. 5. Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC, USA. 6. Division of Gastroenterology, Department of Medicine, Durham Veterans Affairs Medical Center, Durham, NC, USA. 7. Department of Internal Medicine, Durham Veterans Affairs Medical Center, 508 Fulton Street, Durham, NC, 27705, USA. ryan.schulteis@va.gov. 8. Division of General Internal Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA. ryan.schulteis@va.gov.
Abstract
BACKGROUND: The relationship between body mass index (BMI) and cardiopulmonary adverse events (CAEs) for ambulatory colonoscopy is unclear. AIM: To assess the association of BMI and CAEs associated with ambulatory colonoscopy. METHODS: This is a retrospective cohort analysis of 418 patients who underwent outpatient colonoscopy at the Durham Veterans Affairs Medical Center categorized as normal/overweight (BMI < 30), obese (BMI 30-34), or morbidly obese (BMI ≥ 35). Adjusted logistic regression analyses were performed. RESULTS: At least one CAE occurred in 46.4% of patients (220 events, 72.7% were hypoxia). The rate of CAEs (BMI < 30: 43.8%, BMI 30-34: 48.0%, BMI ≥ 35: 50.6%, p = 0.53) and rate of hypoxia (BMI < 30: 34.8%, BMI 30-34: 40.9%, BMI ≥ 35: 43.2%, p = 0.32) were numerically higher for obese and morbidly obese patients, but not statistically significant. Obese (OR 1.10, 95% CI 0.70-1.73) and morbidly obese (OR 1.07, 95% CI 0.61-1.85) patients did not have an increased risk of CAEs after adjusting for age, ASA class, obstructive sleep apnea (OSA), and type of sedation. OSA was independently associated with an increased risk of CAEs (OR 1.71, 95% CI 1.09-2.74, p = 0.02) after adjusting for BMI, age, ASA class, and type of sedation. CONCLUSION: OSA confers a higher risk of CAEs independent of BMI and sedation type. Consideration of undiagnosed OSA is recommended for appropriate pre-procedure risk stratification. While not statistically significant in this study, there may be clinically significant increased risks of CAEs and hypoxia for patient with BMI > 30 that require further evaluation with larger studies.
BACKGROUND: The relationship between body mass index (BMI) and cardiopulmonary adverse events (CAEs) for ambulatory colonoscopy is unclear. AIM: To assess the association of BMI and CAEs associated with ambulatory colonoscopy. METHODS: This is a retrospective cohort analysis of 418 patients who underwent outpatient colonoscopy at the Durham Veterans Affairs Medical Center categorized as normal/overweight (BMI < 30), obese (BMI 30-34), or morbidly obese (BMI ≥ 35). Adjusted logistic regression analyses were performed. RESULTS: At least one CAE occurred in 46.4% of patients (220 events, 72.7% were hypoxia). The rate of CAEs (BMI < 30: 43.8%, BMI 30-34: 48.0%, BMI ≥ 35: 50.6%, p = 0.53) and rate of hypoxia (BMI < 30: 34.8%, BMI 30-34: 40.9%, BMI ≥ 35: 43.2%, p = 0.32) were numerically higher for obese and morbidly obesepatients, but not statistically significant. Obese (OR 1.10, 95% CI 0.70-1.73) and morbidly obese (OR 1.07, 95% CI 0.61-1.85) patients did not have an increased risk of CAEs after adjusting for age, ASA class, obstructive sleep apnea (OSA), and type of sedation. OSA was independently associated with an increased risk of CAEs (OR 1.71, 95% CI 1.09-2.74, p = 0.02) after adjusting for BMI, age, ASA class, and type of sedation. CONCLUSION: OSA confers a higher risk of CAEs independent of BMI and sedation type. Consideration of undiagnosed OSA is recommended for appropriate pre-procedure risk stratification. While not statistically significant in this study, there may be clinically significant increased risks of CAEs and hypoxia for patient with BMI > 30 that require further evaluation with larger studies.
Entities:
Keywords:
Adverse events; Body mass index; Colonoscopy; Patient safety
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