| Literature DB >> 28884327 |
Akira Kudo1,2.
Abstract
Although many studies have described the role of periostin in various diseases, the function of the periostin protein structures derived from alternative splicing and proteinase cleavage at the C-terminal remain unknown. Further experiments revealing the protein structures that are highly related to diseases are essential to understand the function of periostin in depth, which would accelerate its clinical application by establishing new approaches for curing intractable diseases. Furthermore, this understanding would enhance our knowledge of novel functions of periostin related to stemness and response to mechanical stress.Entities:
Keywords: Alternative splicing; Matricellular protein; Periostin; Proteinase cleavage; fas 1 family
Mesh:
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Year: 2017 PMID: 28884327 DOI: 10.1007/s00018-017-2643-5
Source DB: PubMed Journal: Cell Mol Life Sci ISSN: 1420-682X Impact factor: 9.261