BACKGROUND/AIM: The aim of this study was to clarify the treatment strategy for synchronous squamous cell carcinoma of the esophagus (ESCC) and head and neck cancer (HNC). PATIENTS AND METHODS: Treatment outcomes of 91 patients with synchronous ESCC and HNC were evaluated. Thirty-eight patients received simultaneous definitive chemoradiotherapy (CRT) and 15 patients underwent simultaneous resection. RESULTS: Among the patients who received simultaneous CRT, adverse events (grade 3-5) were recognized in 14 patients (40%), including one case of death due to aspiration pneumonia. Complete response was observed in 22 patients with ESCC (58%) and 19 patients with HNC (50%). The five-year survival rate was 44%. There were no in-hospital deaths after simultaneous resection; however, postoperative complications were recognized in 4 patients. The five-year OS was 70%. CONCLUSION: The treatment of synchronous ESCC and HNC must be decided by adopting a strategy that is appropriate for each case. Both simultaneous CRT and simultaneous resection are feasible and effective treatment options. Copyright
BACKGROUND/AIM: The aim of this study was to clarify the treatment strategy for synchronous squamous cell carcinoma of the esophagus (ESCC) and head and neck cancer (HNC). PATIENTS AND METHODS: Treatment outcomes of 91 patients with synchronous ESCC and HNC were evaluated. Thirty-eight patients received simultaneous definitive chemoradiotherapy (CRT) and 15 patients underwent simultaneous resection. RESULTS: Among the patients who received simultaneous CRT, adverse events (grade 3-5) were recognized in 14 patients (40%), including one case of death due to aspiration pneumonia. Complete response was observed in 22 patients with ESCC (58%) and 19 patients with HNC (50%). The five-year survival rate was 44%. There were no in-hospital deaths after simultaneous resection; however, postoperative complications were recognized in 4 patients. The five-year OS was 70%. CONCLUSION: The treatment of synchronous ESCC and HNC must be decided by adopting a strategy that is appropriate for each case. Both simultaneous CRT and simultaneous resection are feasible and effective treatment options. Copyright
Authors: J S Cooper; M D Guo; A Herskovic; J S Macdonald; J A Martenson; M Al-Sarraf; R Byhardt; A H Russell; J J Beitler; S Spencer; S O Asbell; M V Graham; L L Leichman Journal: JAMA Date: 1999-05-05 Impact factor: 56.272
Authors: Arif Deniz Ordu; Carsten Nieder; Hans Geinitz; Vera Scherer; Philipp Günther Kup; Tibor Schuster; Stephanie E Combs; Khashayar Fakhrian Journal: Anticancer Res Date: 2014-12 Impact factor: 2.480
Authors: Y Niwa; M Koike; Y Fujimoto; H Oya; N Iwata; N Nishio; M Hiramatsu; M Kanda; D Kobayashi; C Tanaka; S Yamada; T Fujii; G Nakayama; H Sugimoto; S Nomoto; M Fujiwara; Y Kodera Journal: Dis Esophagus Date: 2015-09-03 Impact factor: 3.429
Authors: R Yoshida; M Morita; K Ando; T Masuda; H Saeki; E Oki; N Sadanaga; T Nakashima; Y Kakeji; Y Maehara Journal: Dis Esophagus Date: 2009-04-15 Impact factor: 3.429
Authors: Christian L Barney; Pedro Zamora; Ashlee Ewing; Matthew Old; Arnab Chakravarti; Aashish Bhatt Journal: Front Oncol Date: 2018-01-08 Impact factor: 6.244