Minh N Pham1, Allison M Deal2, Jed E Ferguson3, Yue Wang4, Angela B Smith5, Matthew E Nielsen6, Raj S Pruthi5, Michael E Woods7. 1. University of North Carolina School of Medicine, Chapel Hill, NC. 2. Lineberger Comprehensive Cancer Center, Biostatistics and Clinical Data Management Core, University of North Carolina, Chapel Hill, NC. 3. Department of Urology, University of North Carolina, Chapel Hill, NC. 4. Department of Biostatistics, University of North Carolina, Chapel Hill, NC. 5. Department of Urology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC. 6. Department of Urology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC; Department of Epidemiology and Health Policy & Management, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC. 7. Department of Urology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC. Electronic address: michael_woods@med.unc.edu.
Abstract
OBJECTIVE: To investigate contemporary survival trends in penile cancer. METHODS: The National Cancer Database was queried for men with penile cancer diagnosed between 1998 and 2009. Patient, tumor, treatment, and facility characteristics were obtained. Overall survival (OS) was analyzed using the Kaplan-Meier method and multivariable Cox proportional hazards regression model for all cases and stratified by stage. RESULTS: A total of 8,122 cases of penile cancer were reported from 1998 to 2009 in the National Cancer Database. Complete staging, survival, and covariate data were available for 5,043 cases. The estimated crude 5-year OS for the entire cohort was 61.0%. For all patients, no significant differences in crude 5-year OS were detected between 2006 to 2009 and 2002 to 2005 compared to 1998 to 2001. On multivariable analysis, OS did not significantly differ across all eras. Regional lymph node dissection was associated with improved OS (hazard ratio [HR] = 0.777, P ≤ 0.0001). In patients who underwent lymph node dissection, dissection of ≥8 nodes significantly improved survival (HR = 0.672; P = 0.0011). Additional modeling stratified by stage revealed that OS for stage II cancers increased significantly in 2006 to 2009 compared to 1998 to 2001 (HR = 0.714; P = 0.0034). CONCLUSIONS: Survival in penile cancer has remained unchanged as a whole and for each stage, except for stage II disease. An improved survival trend was detected in stage II penile cancer. Performing a lymph node dissection, especially extensive dissections, may benefit long-term survival.
OBJECTIVE: To investigate contemporary survival trends in penile cancer. METHODS: The National Cancer Database was queried for men with penile cancer diagnosed between 1998 and 2009. Patient, tumor, treatment, and facility characteristics were obtained. Overall survival (OS) was analyzed using the Kaplan-Meier method and multivariable Cox proportional hazards regression model for all cases and stratified by stage. RESULTS: A total of 8,122 cases of penile cancer were reported from 1998 to 2009 in the National Cancer Database. Complete staging, survival, and covariate data were available for 5,043 cases. The estimated crude 5-year OS for the entire cohort was 61.0%. For all patients, no significant differences in crude 5-year OS were detected between 2006 to 2009 and 2002 to 2005 compared to 1998 to 2001. On multivariable analysis, OS did not significantly differ across all eras. Regional lymph node dissection was associated with improved OS (hazard ratio [HR] = 0.777, P ≤ 0.0001). In patients who underwent lymph node dissection, dissection of ≥8 nodes significantly improved survival (HR = 0.672; P = 0.0011). Additional modeling stratified by stage revealed that OS for stage II cancers increased significantly in 2006 to 2009 compared to 1998 to 2001 (HR = 0.714; P = 0.0034). CONCLUSIONS: Survival in penile cancer has remained unchanged as a whole and for each stage, except for stage II disease. An improved survival trend was detected in stage II penile cancer. Performing a lymph node dissection, especially extensive dissections, may benefit long-term survival.
Authors: Silvia Regina Rogatto; Igor Tsaur; Anita Thomas; Luisa Matos do Canto Alvim; Claudia Aparecida Rainho; Eva Juengel; Roman Alexander Blaheta; Philippe E Spiess Journal: Transl Androl Urol Date: 2021-10
Authors: Andrey Soares; Icaro Thiago de Carvalho; Aluízio Gonçalves da Fonseca; Antonio Machado Alencar; Carlos Heli Bezerra Leite; Diogo Assed Bastos; João Paulo Holanda Soares; Katia Ramos Moreira Leite; Mário Ronalsa Brandão Filho; Ronald Wagner Pereira Coelho; Sandro Roberto de A Cavallero; Stênio de Cassio Zequi; José de Ribamar Rodrigues Calixto Journal: J Cancer Res Clin Oncol Date: 2020-10-26 Impact factor: 4.553