| Literature DB >> 28882671 |
Jinqian Yu1, Xiangyun Song1, Daijie Wang1, Xueyong Wang2, Xiao Wang3.
Abstract
Five new chromone glycosides, officinalisides A (1), B (2), C (3), D (4) and E (5) were isolated from Scindapsus officinalis (Roxb.) Schott., along with six known chromone derivatives, 7-O-α-l-rhamnosyl-nereugenin (6), undulatoside A (7), drynachromoside A (8), drynachromoside B (9), 5,7-dihydroxy-2-methyl chromone(10), 5,7-dihydroxy-2-hydroxymethyl chromone (11). Structural elucidation of the isolated compounds was established by spectroscopic analysis, especially 2D NMR techniques and comparison with literatures. The isolates were evaluated for anti-inflammatory activities in a LPS-stimulated RAW 264.7 model using inhibition of nitric oxide (NO) production as an indicator. Compounds 2, 4 and 10 demonstrated potential anti-inflammatory activity with IC50 values of 16.1, 19.1, and 13.4μM, respectively, compared to the positive control dexamethasone.Entities:
Keywords: Anti-inflammatory activity; Chromone glycoside; Officinaliside A; Officinaliside B; Officinaliside C; Officinaliside D; Officinaliside E; Scindapsus officinalis
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Year: 2017 PMID: 28882671 DOI: 10.1016/j.fitote.2017.09.002
Source DB: PubMed Journal: Fitoterapia ISSN: 0367-326X Impact factor: 2.882