Gian Candrian1, Andreas Müller2, Patrizia Dall'Acqua3, Kyveli Kompatsiari2, Gian-Marco Baschera2, Ladislav Mica4, Hans-Peter Simmen4, Richard Glaab5, Javier Fandino6, Markus Schwendinger7, Christoph Meier8, Erika Jasmin Ulbrich9, Sönke Johannes10. 1. Brain and Trauma Foundation Grisons, Poststrasse 22, CH-7000 Chur, Switzerland. Electronic address: giancan@bluewin.ch. 2. Brain and Trauma Foundation Grisons, Poststrasse 22, CH-7000 Chur, Switzerland. 3. Bellikon Rehabilitation Clinic, CH-5454 Bellikon, Switzerland; Division Neuropsychology, Department of Psychology, University of Zurich, CH-8050 Zurich, Switzerland. 4. Division of Trauma Surgery, University Hospital Zurich, CH-8091 Zurich, Switzerland. 5. Department of Traumatology, Cantonal Hospital Aarau, CH-5001 Aarau, Switzerland. 6. Department of Neurosurgery, Cantonal Hospital Aarau, CH-5001 Aarau, Switzerland. 7. Interdisciplinary Emergency Centre, Baden Cantonal Hospital, CH-5404 Baden, Switzerland. 8. Department of Surgery, Waid City Hospital, CH-8037 Zurich, Switzerland. 9. Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, CH-8091 Zurich, Switzerland. 10. Bellikon Rehabilitation Clinic, CH-5454 Bellikon, Switzerland.
Abstract
BACKGROUND: Event-related potentials have repeatedly revealed electrophysiological markers of cognitive dysfunction associated with Mild Traumatic Brain Injury (MTBI) and may represent a sensitive tool to guide cognitive rehabilitative interventions. We previously found patients with symptomatic MTBI characterized by smaller P300 (or P3) wave amplitudes in a NoGo-P3 subcomponent in the acute phase of the injury. The goal of this longitudinal study was to investigate whether this early NoGo-P3 subcomponent differs over time in symptomatic MTBI patients and healthy controls. METHODS: We included adults with a diagnosis of MTBI and individually matched healthy controls tested at 1 week, 3 months, and 1 year after the MTBI. Symptoms were assessed by the Rivermead Post-Concussion Symptoms Questionnaire. NoGo-P3 was collected by using a cued Go/NoGo task and the relevant subcomponent was extracted by independent component analysis. RESULTS: Among 53 adults with a diagnosis of MTBI and 53 controls, we included 35 with symptomatic MTBI and 35 matched healthy controls (18 females each group; mean age 34.06±13.15 and 34.26±12.98 years). Amplitudes for the early NoGo-P3 subcomponent were lower for symptomatic MTBI patients than controls (P<0.05) at 1 week post-injury. Furthermore, mixed ANOVA revealed a significant time by group interaction (P<0.05), so the effect of time differed for symptomatic MTBI patients and healthy controls. The amplitudes for MTBI patients normalized from 1 week to 3 months post-injury and were comparable to those of controls from 3 months to 1 year post-injury. However, amplitudes for 3 MTBI patients with particularly severe complaints 1 year post-injury did not normalize and were lower than those for the remaining MTBI sample (P<0.05). CONCLUSIONS: Selected event-related potentials can be used as a sensitive and objective tool to illustrate the cognitive consequences of and recovery after MTBI.
BACKGROUND: Event-related potentials have repeatedly revealed electrophysiological markers of cognitive dysfunction associated with Mild Traumatic Brain Injury (MTBI) and may represent a sensitive tool to guide cognitive rehabilitative interventions. We previously found patients with symptomatic MTBI characterized by smaller P300 (or P3) wave amplitudes in a NoGo-P3 subcomponent in the acute phase of the injury. The goal of this longitudinal study was to investigate whether this early NoGo-P3 subcomponent differs over time in symptomatic MTBI patients and healthy controls. METHODS: We included adults with a diagnosis of MTBI and individually matched healthy controls tested at 1 week, 3 months, and 1 year after the MTBI. Symptoms were assessed by the Rivermead Post-Concussion Symptoms Questionnaire. NoGo-P3 was collected by using a cued Go/NoGo task and the relevant subcomponent was extracted by independent component analysis. RESULTS: Among 53 adults with a diagnosis of MTBI and 53 controls, we included 35 with symptomatic MTBI and 35 matched healthy controls (18 females each group; mean age 34.06±13.15 and 34.26±12.98 years). Amplitudes for the early NoGo-P3 subcomponent were lower for symptomatic MTBI patients than controls (P<0.05) at 1 week post-injury. Furthermore, mixed ANOVA revealed a significant time by group interaction (P<0.05), so the effect of time differed for symptomatic MTBI patients and healthy controls. The amplitudes for MTBI patients normalized from 1 week to 3 months post-injury and were comparable to those of controls from 3 months to 1 year post-injury. However, amplitudes for 3 MTBI patients with particularly severe complaints 1 year post-injury did not normalize and were lower than those for the remaining MTBI sample (P<0.05). CONCLUSIONS: Selected event-related potentials can be used as a sensitive and objective tool to illustrate the cognitive consequences of and recovery after MTBI.
Authors: James F Cavanagh; J Kevin Wilson; Rebecca E Rieger; Darbi Gill; James M Broadway; Jacqueline Hope Story Remer; Violet Fratzke; Andrew R Mayer; Davin K Quinn Journal: Neuropsychologia Date: 2019-06-19 Impact factor: 3.139