Literature DB >> 28881158

Long noncoding RNA DLX6-AS1 promotes renal cell carcinoma progression via miR-26a/PTEN axis.

Xing Zeng1, Zhiquan Hu1, Xinwen Ke1, Huake Tang1, Bolin Wu1, Xian Wei1, Zheng Liu1.   

Abstract

Recently, long non-coding RNAs (lncRNAs) have emerged as new gene regulators and prognostic markers in several types of cancer, including renal cell carcinoma (RCC). In this study, we identified an upregulated lncRNA, DLX6-AS1, in RCC tumor tissues compared with normal kidney tissues. Our data suggested that DLX6-AS1 promoted RCC cell growth and tumorigenesis via targeting miR-26a. In addition, we observed that PTEN overexpression restored the renal cancer cell growth and also rescued the RCC tumorigenesis. In summary, we conclude that DLX6-AS1 promotes renal cell carcinoma development via regulation of miR-26a/PTEN axis.

Entities:  

Keywords:  DLX6-AS1; Long non-coding RNA; PTEN; RCC; Renal cell carcinoma; miR-26a

Mesh：

Substances：

Year:  2017        PMID： 28881158      PMCID： PMC5736339          DOI： 10.1080/15384101.2017.1361072

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  36 in total

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3.  MiR-26a inhibits stem cell-like phenotype and tumor growth of osteosarcoma by targeting Jagged1.

Authors:  J Lu; G Song; Q Tang; J Yin; C Zou; Z Zhao; X Xie; H Xu; G Huang; J Wang; D-F Lee; R Khokha; H Yang; J Shen
Journal:  Oncogene       Date:  2016-06-06       Impact factor: 9.867

4.  Down-regulated miR-26a promotes proliferation, migration, and invasion via negative regulation of MTDH in esophageal squamous cell carcinoma.

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5.  MiR-26a enhances invasive capacity by suppressing GSK3β in human lung cancer cells.

Authors:  Gaoyang Lin; Boning Liu; Zhaowei Meng; Yunde Liu; Xuebing Li; Xiang Wu; Qinghua Zhou; Ke Xu
Journal:  Exp Cell Res       Date:  2017-02-21       Impact factor: 3.905

6.  Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205.

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Journal:  Cancer Res       Date:  2015-01-19       Impact factor: 12.701

7.  miR-26a and miR-214 down-regulate expression of the PTEN gene in chronic lymphocytic leukemia, but not PTEN mutation or promoter methylation.

Authors:  Zhi-Jian Zou; Lei Fan; Li Wang; Ji Xu; Run Zhang; Tian Tian; Jian-Yong Li; Wei Xu
Journal:  Oncotarget       Date:  2015-01-20

8.  MiR-26 enhances chemosensitivity and promotes apoptosis of hepatocellular carcinoma cells through inhibiting autophagy.

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9.  Long intergenic non-protein coding RNA 00858 functions as a competing endogenous RNA for miR-422a to facilitate the cell growth in non-small cell lung cancer.

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10.  Corrigendum: Extensive microRNA-mediated crosstalk between lncRNAs and mRNAs in mouse embryonic stem cells.

Authors:  Jennifer Y Tan; Tamara Sirey; Frantisek Honti; Bryony Graham; Allison Piovesan; Matthias Merkenschlager; Caleb Webber; Chris P Ponting; Ana C Marques
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  25 in total

1.  DLX6-AS1/miR-204-5p/OCT1 positive feedback loop promotes tumor progression and epithelial-mesenchymal transition in gastric cancer.

Authors:  Yu Liang; Chun-Dong Zhang; Cheng Zhang; Dong-Qiu Dai
Journal:  Gastric Cancer       Date:  2019-08-28       Impact factor: 7.370

Review 2.  Promising long noncoding RNA DLX6-AS1 in malignant tumors.

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Journal:  Am J Transl Res       Date:  2020-12-15       Impact factor: 4.060

3.  LncRNA DLX6-AS1 promotes laryngeal squamous cell carcinoma growth and invasion through regulating miR-376c.

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Journal:  Am J Transl Res       Date:  2019-11-15       Impact factor: 4.060

4.  Long noncoding RNA DLX6-AS1 targets miR-124-3p/CDK4 to accelerate Ewing's sarcoma.

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5.  Long non-coding RNA LINC01410 promotes colon cancer cell proliferation and invasion by inhibiting miR-3128.

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Review 7.  Strategies of LncRNA DLX6-AS1 on Study and Therapeutics.

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Journal:  Front Genet       Date:  2022-06-01       Impact factor: 4.772

8.  LncRNA DLX6-AS1 Promotes Malignant Phenotype and Lymph Node Metastasis in Prostate Cancer by Inducing LARGE Methylation.

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9.  Long non-coding RNA GAS5 sensitizes renal cell carcinoma to sorafenib via miR-21/SOX5 pathway.

Authors:  Lei Liu; Xinlu Pang; Wenjin Shang; Hongchang Xie; Yonghua Feng; Guiwen Feng
Journal:  Cell Cycle       Date:  2019-01-29       Impact factor: 4.534

10.  Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Renal Cell Carcinoma Progression via Sponging miRNA-429.

Authors:  Lin-Tao Jiang; Chun-Hua Wan; Qing-Hao Guo; Shi-Jiang Yang; Jing-Dong Wu; Jun Cai
Journal:  Med Sci Monit       Date:  2018-03-28
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