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Literature DB >> 28880316

A modular design for minor groove binding and recognition of mixed base pair sequences of DNA.

Pu Guo¹, Ananya Paul¹, Arvind Kumar¹, Narinder K Harika¹, Siming Wang¹, Abdelbasset A Farahat¹, David W Boykin¹, W David Wilson¹.

Abstract

The design and synthesis of compounds that target mixed, AT/GC, DNA sequences is described. The design concept connects two N-methyl-benzimidazole-thiophene single GC recognition units with a flexible linker that lets the compound fit the shape and twist of the DNA minor groove while covering a full turn of the double helix.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2017 PMID： 28880316 PMCID： PMC5616130 DOI： 10.1039/c7cc06246j

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

30 in total

Review 1. Chemical approaches to the discovery and development of cancer therapies.

Authors: Stephen Neidle; David E Thurston
Journal: Nat Rev Cancer Date: 2005-04 Impact factor: 60.716

Review 2. Targeting higher-order DNA: beyond the G-quadruplex.

Authors: Lesley A Howell; Mark Searcey
Journal: Chembiochem Date: 2009-09-04 Impact factor: 3.164

3. Water-mediated binding of agents that target the DNA minor groove.

Authors: Yang Liu; Arvind Kumar; Sabine Depauw; Raja Nhili; Marie-Hélène David-Cordonnier; Michael P Lee; Mohamed A Ismail; Abdelbasset A Farahat; Martial Say; Sarah Chackal-Catoen; Adalgisa Batista-Parra; Stephen Neidle; David W Boykin; W David Wilson
Journal: J Am Chem Soc Date: 2011-06-15 Impact factor: 15.419

4. B-lymphocyte-induced maturation protein1 up-regulates the expression of B-cell maturation antigen in mouse plasma cells.

Authors: Shaoli Deng; Tao Yuan; Xiaoxing Cheng; Rui Jian; Jing Jiang
Journal: Mol Biol Rep Date: 2010-03-26 Impact factor: 2.316

5. Molecular dynamics simulations and thermodynamics analysis of DNA-drug complexes. Minor groove binding between 4',6-diamidino-2-phenylindole and DNA duplexes in solution.

Authors: Nad'a Spacková; Thomas E Cheatham; Filip Ryjácek; Filip Lankas; Luc Van Meervelt; Pavel Hobza; Jirí Sponer
Journal: J Am Chem Soc Date: 2003-02-19 Impact factor: 15.419

6. B lymphocyte-induced maturation protein (Blimp)-1, IFN regulatory factor (IRF)-1, and IRF-2 can bind to the same regulatory sites.

Authors: Tracy C Kuo; Kathryn L Calame
Journal: J Immunol Date: 2004-11-01 Impact factor: 5.422

Review 7. Binding to the DNA minor groove by heterocyclic dications: from AT-specific monomers to GC recognition with dimers.

Authors: Rupesh Nanjunda; W David Wilson
Journal: Curr Protoc Nucleic Acid Chem Date: 2012-12

8. Molecular dynamics of water-mediated interactions of a linear benzimidazole-biphenyl diamidine with the DNA minor groove.

Authors: Prashanth Athri; W David Wilson
Journal: J Am Chem Soc Date: 2009-06-10 Impact factor: 15.419

4. Engineered modular heterocyclic-diamidines for sequence-specific recognition of mixed AT/GC base pairs at the DNA minor groove.

Authors: Pu Guo; Abdelbasset A Farahat; Ananya Paul; David W Boykin; W David Wilson
Journal: Chem Sci Date: 2021-11-02 Impact factor: 9.825

4 in total

A modular design for minor groove binding and recognition of mixed base pair sequences of DNA.

Review 1. Chemical approaches to the discovery and development of cancer therapies.

Review 2. Targeting higher-order DNA: beyond the G-quadruplex.

3. Water-mediated binding of agents that target the DNA minor groove.

4. B-lymphocyte-induced maturation protein1 up-regulates the expression of B-cell maturation antigen in mouse plasma cells.

5. Molecular dynamics simulations and thermodynamics analysis of DNA-drug complexes. Minor groove binding between 4',6-diamidino-2-phenylindole and DNA duplexes in solution.

6. B lymphocyte-induced maturation protein (Blimp)-1, IFN regulatory factor (IRF)-1, and IRF-2 can bind to the same regulatory sites.

Review 7. Binding to the DNA minor groove by heterocyclic dications: from AT-specific monomers to GC recognition with dimers.

8. Molecular dynamics of water-mediated interactions of a linear benzimidazole-biphenyl diamidine with the DNA minor groove.

Review 9. DNA minor groove binders: back in the groove.

10. Sequence- and structural-selective nucleic acid binding revealed by the melting of mixtures.

1. Thermodynamic Factors That Drive Sequence-Specific DNA Binding of Designed, Synthetic Minor Groove Binding Agents.

2. Bound Compound, Interfacial Water, and Phenyl Ring Rotation Dynamics of a Compound in the DNA Minor Groove.

3. DNA-binding miniproteins based on zinc fingers. Assessment of the interaction using nanopores.

4. Engineered modular heterocyclic-diamidines for sequence-specific recognition of mixed AT/GC base pairs at the DNA minor groove.