| Literature DB >> 28879630 |
Marta Bielska1, Maciej Borowiec2, Dorota Jesionek-Kupnicka3, Marcin Braun1,3,4, Marcin Bojo5, Agata Pastorczak1, Ewa Kalinka-Warzocha5, Monika Prochorec-Sobieszek6, Tadeusz Robak7, Krzysztof Warzocha8, Wojciech Młynarski9, Ewa Lech-Marańda8,10.
Abstract
IKZF1 encodes a transcription factor involved in B-cell maturation and differentiation. We genotyped 218 diffuse large B-cell lymphoma (DLBCL) patients and 715 unrelated controls using a TaqMan allelic discrimination assay. No statistical difference was observed in the genotype distribution of the IKZF1 rs4132601 polymorphism between DLBCL patients and controls. However, the 2-year PFS rate of patients with the IKZF1 TT genotype was 54.3% compared to 68.6% in those with the IKZF1 G+ genotypes. Moreover, the IKZF1 rs4132601 polymorphism retained its independent prognostic impact on PFS. A more pronounced effect of the IKZF1 TT genotype on PFS was detected in patients with low/intermediate low IPI-risk group. When analysis was restricted to patients with GCB-type pattern, those with the IKZF1 TT genotype achieved a lower 5-year OS rate than the patients with the IKZF1 G+ genotypes (19.6 vs. 56%). This study provides the first evidence for the association of IKZF1 variants with DLBCL outcome.Entities:
Keywords: Diffuse large B-cell lymphoma; Gene polymorphism; IKZF1
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Year: 2017 PMID： 28879630 DOI： 10.1007/s12185-017-2315-0
Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490