Florence Santiagu1,2, Azam Bakhtiari3, Tajunisah Iqbal3, Nurliza Khaliddin3, Van C Lansingh4, Visvaraja Subrayan3. 1. University Malaya Medical Center, Lembah Pantai, 59100, Kuala Lumpur, Malaysia. florencesantiagu@gmail.com. 2. Shah Alam Hospital, Persiaran Kayangan, Seksyen 7, 40000, Shah Alam, Selangor, Malaysia. florencesantiagu@gmail.com. 3. University Malaya Medical Center, Lembah Pantai, 59100, Kuala Lumpur, Malaysia. 4. University of Miami, 1320 S Dixie Hwy, Coral Gables, FL, 33146, USA.
Abstract
BACKGROUND: Purpose of this study is to evaluate changes in the central corneal thickness (CCT) in patients during the third trimester and postpartum phases of normal pregnancy, pregestational diabetes mellitus (DM), and gestational diabetes mellitus (GDM). METHODS: This was a prospective study. Patients that fulfilled the inclusion criteria were recruited from the obstetric clinic. They were grouped into normal pregnancy, pregestational DM, and GDM. Ophthalmic assessment and haematological investigations were done during the third trimester (after 28 weeks of gestation) and in the postpartum phase (6 weeks postpartum). RESULTS: A total of 192 pregnant patients were recruited for this study. Out of the 192 patients, only 143 of them came back for their follow-up 6 weeks postpartum. A total of 70 (36.5%) normal pregnancy patients, 51 (26.6%) DM patients, and 71 (36.9%) GDM patients were included in this prospective study. Our study showed that the CCT decreased postpartum in all three groups. Patients in all three groups did not have significantly different CCT during the third trimester of pregnancy and postpartum phase. However, patients who had thicker CCT irrespective of the grouping during the third trimester also had a thicker CCT post-delivery (p value <0.001). However, these changes did not appear to affect refractive error and visual acuity. CONCLUSIONS: Diabetes mellitus during pregnancy did not appear to influence the CCT.
BACKGROUND: Purpose of this study is to evaluate changes in the central corneal thickness (CCT) in patients during the third trimester and postpartum phases of normal pregnancy, pregestational diabetes mellitus (DM), and gestational diabetes mellitus (GDM). METHODS: This was a prospective study. Patients that fulfilled the inclusion criteria were recruited from the obstetric clinic. They were grouped into normal pregnancy, pregestational DM, and GDM. Ophthalmic assessment and haematological investigations were done during the third trimester (after 28 weeks of gestation) and in the postpartum phase (6 weeks postpartum). RESULTS: A total of 192 pregnant patients were recruited for this study. Out of the 192 patients, only 143 of them came back for their follow-up 6 weeks postpartum. A total of 70 (36.5%) normal pregnancy patients, 51 (26.6%) DMpatients, and 71 (36.9%) GDM patients were included in this prospective study. Our study showed that the CCT decreased postpartum in all three groups. Patients in all three groups did not have significantly different CCT during the third trimester of pregnancy and postpartum phase. However, patients who had thicker CCT irrespective of the grouping during the third trimester also had a thicker CCT post-delivery (p value <0.001). However, these changes did not appear to affect refractive error and visual acuity. CONCLUSIONS:Diabetes mellitus during pregnancy did not appear to influence the CCT.
Entities:
Keywords:
Cornea; Estrogen; Gestational diabetes; Pregnancy in diabetics; Visual acuity
Authors: T Suzuki; Y Kinoshita; M Tachibana; Y Matsushima; Y Kobayashi; W Adachi; C Sotozono; S Kinoshita Journal: Curr Eye Res Date: 2001-01 Impact factor: 2.424
Authors: Daniel H W Su; Tien Y Wong; Wan-Ling Wong; Seang-Mei Saw; Donald T H Tan; Sunny Y Shen; Seng-Chee Loon; Paul J Foster; Tin Aung Journal: Ophthalmology Date: 2007-10-26 Impact factor: 12.079