Adam E M Eltorai1,2. 1. Department of Orthopaedics, Warren Alpert Medical School of Brown University, United States. 2. Biomedical Engineering, Brown University, United States.
Abstract
OBJECTIVE: Surgical instrumentation of the spine is susceptible to infection. Intravenous antibiotics is a current mainstay of treating infection; however penetrating the bacterial biofilm and directly targeting the source of the infection is challenging. METHODS: Using multiple reservoirs of discrete drug doses, microchips represent a new technology capable of on-demand drug release over long periods of time. RESULTS: A novel solution of integrating vancomycin-eluting microchips into pedicle screws in order directly target and treat spinal infections is proposed. CONCLUSION: This drug-releasing implant has the potential to provide the particular benefit to high-infection-risk patients in order to avoid reoperation.
OBJECTIVE: Surgical instrumentation of the spine is susceptible to infection. Intravenous antibiotics is a current mainstay of treating infection; however penetrating the bacterial biofilm and directly targeting the source of the infection is challenging. METHODS: Using multiple reservoirs of discrete drug doses, microchips represent a new technology capable of on-demand drug release over long periods of time. RESULTS: A novel solution of integrating vancomycin-eluting microchips into pedicle screws in order directly target and treat spinal infections is proposed. CONCLUSION: This drug-releasing implant has the potential to provide the particular benefit to high-infection-risk patients in order to avoid reoperation.
Entities:
Keywords:
Drug delivery; Implant; On-demand; Spinal screw; Spine surgery
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