| Literature DB >> 2887725 |
M H Munshi, D A Sack, K Haider, Z U Ahmed, M M Rahaman, M G Morshed.
Abstract
In an epidemic of shigellosis in southern Bangladesh the causal organism, Shigella dysenteriae type 1, was resistant to nalidixic acid as well as to co-trimoxazole (trimethoprimsulphamethoxazole) and ampicillin. The genes coding for resistance to nalidixic acid, but not those coding for resistance to co-trimoxazole or ampicillin, are located on a conjugative 20 megadalton plasmid. This epidemic is of particular importance because of the resistance to nalidixic acid, an antibiotic to which shigellae are seldom resistant, and because plasmids were previously thought not to mediate resistance to nalidixic acid.Entities:
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Year: 1987 PMID： 2887725 DOI： 10.1016/s0140-6736(87)90957-3
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321