Björn A Blomberg1, Anders Thomassen, Pim A de Jong, Marnix G E Lam, Axel C P Diederichsen, Michael H Olsen, Hans Mickley, Willem P T M Mali, Abass Alavi, Poul F Høilund-Carlsen. 1. Departments of aNuclear Medicine bCardiology cCenter for Individualized Medicine in Arterial Diseases, Odense University Hospital dInstitute of Clinical Research, University of Southern Denmark, Odense eDepartment of Internal Medicine, Holbaek Hospital, Holbaek, Denmark fDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands gDepartment of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Abstract
OBJECTIVE: Coronary artery fluorine-18-sodium fluoride (F-NaF) uptake reflects coronary artery calcification metabolism and is considered to be an early prognostic marker of coronary heart disease. This study evaluated the relationship between coronary artery F-NaF uptake and cardiovascular risk in healthy adults at low cardiovascular risk. PARTICIPANTS AND METHODS: Study participants underwent blood pressure measurements, blood analyses, and coronary artery F-NaF PET/CT imaging. In addition, the 10-year risk for the development of cardiovascular disease, on the basis of the Framingham Risk Score, was estimated. Multivariable linear regression evaluated the dependence of coronary artery F-NaF uptake on cardiovascular risk factors. RESULTS: We recruited 89 (47 men, 42 women) healthy adults aged 21-75 years. Female sex (0.34 kBq/ml; P=0.009), age (0.16 kBq/ml per SD; P=0.002), and BMI (0.42 kBq/ml per SD; P<0.001) were independent determinants of increased coronary artery F-NaF uptake (adjusted R=0.21; P<0.001). Coronary artery F-NaF uptake increased linearly according to the number of cardiovascular risk factors present (P<0.001 for a linear trend). The estimated 10-year risk for the development of cardiovascular disease was on average 2.4 times higher in adults with coronary artery F-NaF uptake in the highest quartile compared with those in the lowest quartile of the distribution (8.0 vs. 3.3%, P<0.001). CONCLUSION: Our findings indicate that coronary artery F-NaF PET/CT imaging is feasible in healthy adults at low cardiovascular risk and that an unfavorable cardiovascular risk profile is associated with a marked increase in coronary artery F-NaF uptake.
OBJECTIVE: Coronary artery fluorine-18-sodium fluoride (F-NaF) uptake reflects coronary artery calcification metabolism and is considered to be an early prognostic marker of coronary heart disease. This study evaluated the relationship between coronary artery F-NaF uptake and cardiovascular risk in healthy adults at low cardiovascular risk. PARTICIPANTS AND METHODS: Study participants underwent blood pressure measurements, blood analyses, and coronary artery F-NaF PET/CT imaging. In addition, the 10-year risk for the development of cardiovascular disease, on the basis of the Framingham Risk Score, was estimated. Multivariable linear regression evaluated the dependence of coronary artery F-NaF uptake on cardiovascular risk factors. RESULTS: We recruited 89 (47 men, 42 women) healthy adults aged 21-75 years. Female sex (0.34 kBq/ml; P=0.009), age (0.16 kBq/ml per SD; P=0.002), and BMI (0.42 kBq/ml per SD; P<0.001) were independent determinants of increased coronary artery F-NaF uptake (adjusted R=0.21; P<0.001). Coronary artery F-NaF uptake increased linearly according to the number of cardiovascular risk factors present (P<0.001 for a linear trend). The estimated 10-year risk for the development of cardiovascular disease was on average 2.4 times higher in adults with coronary artery F-NaF uptake in the highest quartile compared with those in the lowest quartile of the distribution (8.0 vs. 3.3%, P<0.001). CONCLUSION: Our findings indicate that coronary artery F-NaF PET/CT imaging is feasible in healthy adults at low cardiovascular risk and that an unfavorable cardiovascular risk profile is associated with a marked increase in coronary artery F-NaF uptake.
Authors: Abdullah Al-Zaghal; Dani P Yellanki; Esha Kothekar; Thomas J Werner; Poul F Høilund-Carlsen; Abass Alavi Journal: Asia Ocean J Nucl Med Biol Date: 2019
Authors: Michael Mayer; Austin J Borja; Emily C Hancin; Thomas Auslander; Mona-Elisabeth Revheim; Mateen C Moghbel; Thomas J Werner; Abass Alavi; Chamith S Rajapakse Journal: Front Physiol Date: 2020-10-22 Impact factor: 4.566
Authors: Richard A P Takx; Ruth van Asperen; Jonas W Bartstra; Sabine R Zwakenberg; Jelmer M Wolterink; Csilla Celeng; Pim A de Jong; Joline W Beulens Journal: J Nucl Cardiol Date: 2020-03-17 Impact factor: 5.952