Fatma Demir Duman1, Merve Erkisa2, Rouhullah Khodadust1, Ferda Ari2, Engin Ulukaya3, Havva Yagci Acar1,4. 1. Department of Chemistry, Koc University, Istanbul 34450, Turkey. 2. Department of Biology, Uludag University, Bursa 16059, Turkey. 3. Department of Clinical Biochemistry, School of Medicine, Istinye University, Istanbul 34010, Turkey. 4. Koc University Surface Science & Technology Center (KUYTAM), Istanbul 34450, Turkey.
Abstract
AIM: We aim to develop folic acid (FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region. MATERIALS & METHODS: Cationic Ag2S NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells. RESULTS: Significantly higher uptake of DOX by human cervical carcinoma cells cells and a greater therapeutic effect along with a strong intracellular optical signal were obtained with DOX-loaded FA-conjugated Ag2S NIRQDs. CONCLUSION: These Ag2S NIRQDs are promising theranostic nanoparticles for receptor-mediated delivery of DOX with enhanced drug efficacy combined with optical imaging.
AIM: We aim to develop folic acid (FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region. MATERIALS & METHODS: Cationic Ag2S NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells. RESULTS: Significantly higher uptake of DOX by human cervical carcinoma cells cells and a greater therapeutic effect along with a strong intracellular optical signal were obtained with DOX-loaded FA-conjugated Ag2S NIRQDs. CONCLUSION: These Ag2S NIRQDs are promising theranostic nanoparticles for receptor-mediated delivery of DOX with enhanced drug efficacy combined with optical imaging.
Entities:
Keywords:
Ag2S quantum dots; cancer therapy; doxorubicin; near-infrared imaging; targeting
Authors: Lee B Sims; Keegan C Curry; Sindhu Parupalli; Gwynneth Horner; Hermann B Frieboes; Jill M Steinbach-Rankins Journal: Pharm Res Date: 2019-03-13 Impact factor: 4.200