Zhuo Zhang1, Runlan Luo2, Bijun Tan2, Jing Qian1, Yanfang Duan1, Nan Wang2, Guangsen Li3. 1. Department of Radiation Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China. 2. Department of Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, China. 3. Department of Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, China. liguangsen009@163.com.
Abstract
PURPOSE: This study aims to assess carotid elasticity early in normal left ventricular function in post-radiotherapy patients with nasopharyngeal carcinoma (NPC) by wave intensity. METHODS: Sixty-seven post-radiotherapy patients all with normal left ventricular function were classified into group NPC1 and group NPC2 based on their carotid intima-media thickness. Thirty age- and sex-matched NPC patients without any history of irradiation and chemotherapy were included as a control group. Carotid parameters, including stiffness constant (β), pressure-strain elastic modulus (Ep), arterial compliance (AC), stiffness constant pulse wave velocity (PWVβ), and wave intensity pulse wave velocity (PWVWI) were measured. RESULTS: There were no significant differences in conventional echocardiographic variables among the three groups. In comparison with the control group, β, Ep, PWVβ, and PWVWI were significantly increased, while AC was significantly decreased in the NPC1 and NPC2 groups, and there were differences between the NPC1 group and NPC2 group (all P < 0.05). CONCLUSION: This study suggested that carotid artery stiffness increased with reduced carotid compliance in post-RT with NPC.
PURPOSE: This study aims to assess carotid elasticity early in normal left ventricular function in post-radiotherapy patients with nasopharyngeal carcinoma (NPC) by wave intensity. METHODS: Sixty-seven post-radiotherapy patients all with normal left ventricular function were classified into group NPC1 and group NPC2 based on their carotid intima-media thickness. Thirty age- and sex-matched NPCpatients without any history of irradiation and chemotherapy were included as a control group. Carotid parameters, including stiffness constant (β), pressure-strain elastic modulus (Ep), arterial compliance (AC), stiffness constant pulse wave velocity (PWVβ), and wave intensity pulse wave velocity (PWVWI) were measured. RESULTS: There were no significant differences in conventional echocardiographic variables among the three groups. In comparison with the control group, β, Ep, PWVβ, and PWVWI were significantly increased, while AC was significantly decreased in the NPC1 and NPC2 groups, and there were differences between the NPC1 group and NPC2 group (all P < 0.05). CONCLUSION: This study suggested that carotid artery stiffness increased with reduced carotid compliance in post-RT with NPC.
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