Quanliang Shang1,2, Shivani Patel1, Michael Steinmetz3, Andreas Schuster4, David A Danford1, Philipp Beerbaum5, Samir Sarikouch5, Shelby Kutty6. 1. Division of Pediatric Cardiology, University of Nebraska College of Medicine, Children's Hospital and Medical Center, Omaha, NE, USA. 2. Department of Radiology, Second Xiangya Hospital, Central South University , Changsha, Hunan Province, China. 3. Department of Paediatric Cardiology, Georg-August-University and German Centre for Cardiovascular Research (DZHK, Partner Site), Göttingen, Germany. 4. Department of Cardiology and Pulmonology, Georg-August-University and German Centre for Cardiovascular Research (DZHK, Partner Site), Göttingen, Germany. 5. Hanover Medical School, Hanover, Germany. 6. Division of Pediatric Cardiology, University of Nebraska College of Medicine, Children's Hospital and Medical Center, Omaha, NE, USA. skutty@unmc.edu.
Abstract
PURPOSE: Left ventricular two-dimensional global longitudinal strain (LS) is superior to ejection fraction (EF) as predictor of outcome. We provide reference data for atrial and ventricular global LS during childhood and adolescence by CMR feature tracking (FT). METHODS: We prospectively enrolled 115 healthy subjects (56 male, mean age 12.4 ± 4.1 years) at a single institution. CMR consisted of standard two-dimensional steady-state free-precession acquisitions. CMR-FT was performed on ventricular horizontal long-axis images for derivation of right and left atrial (RA, LA) and right and left ventricular (RV, LV) peak global LS. End-diastolic volumes (EDVs) and EF were measured. Correlations were explored for LS with age, EDV and EF of each chamber. RESULTS: Mean±SD of LS (%) for RA, RV, LA and LV were 26.56±10.2, -17.96±5.4, 26.45±10.6 and -17.47±5, respectively. There was a positive correlation of LS in LA, LV, RA and RV with corresponding EF (all P<0.05); correlations with age were weak. Gender-wise differences were not significant for atrial and ventricular LS, strain rate and displacement. Inter- and intra-observer comparisons showed moderate agreements. CONCLUSIONS: Chamber-specific nomograms for paediatric atrial and ventricular LS are provided to serve as clinical reference, and to facilitate CMR-based deformation research. KEY POINTS: • No normative data exist for CMR-derived global longitudinal strain in the young. • This prospective study provides reference data for atrial and ventricular longitudinal strain. • The data will serve as reference for CMR-based clinical and research use.
PURPOSE: Left ventricular two-dimensional global longitudinal strain (LS) is superior to ejection fraction (EF) as predictor of outcome. We provide reference data for atrial and ventricular global LS during childhood and adolescence by CMR feature tracking (FT). METHODS: We prospectively enrolled 115 healthy subjects (56 male, mean age 12.4 ± 4.1 years) at a single institution. CMR consisted of standard two-dimensional steady-state free-precession acquisitions. CMR-FT was performed on ventricular horizontal long-axis images for derivation of right and left atrial (RA, LA) and right and left ventricular (RV, LV) peak global LS. End-diastolic volumes (EDVs) and EF were measured. Correlations were explored for LS with age, EDV and EF of each chamber. RESULTS: Mean±SD of LS (%) for RA, RV, LA and LV were 26.56±10.2, -17.96±5.4, 26.45±10.6 and -17.47±5, respectively. There was a positive correlation of LS in LA, LV, RA and RV with corresponding EF (all P<0.05); correlations with age were weak. Gender-wise differences were not significant for atrial and ventricular LS, strain rate and displacement. Inter- and intra-observer comparisons showed moderate agreements. CONCLUSIONS: Chamber-specific nomograms for paediatric atrial and ventricular LS are provided to serve as clinical reference, and to facilitate CMR-based deformation research. KEY POINTS: • No normative data exist for CMR-derived global longitudinal strain in the young. • This prospective study provides reference data for atrial and ventricular longitudinal strain. • The data will serve as reference for CMR-based clinical and research use.
Authors: Andreas Schuster; Kan N Hor; Johannes T Kowallick; Philipp Beerbaum; Shelby Kutty Journal: Circ Cardiovasc Imaging Date: 2016-04 Impact factor: 7.792
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Authors: Shelby Kutty; Sheela Rangamani; Jeeva Venkataraman; Ling Li; Andreas Schuster; Scott E Fletcher; David A Danford; Philipp Beerbaum Journal: Int J Cardiovasc Imaging Date: 2012-05-12 Impact factor: 2.357
Authors: Joseph T Poterucha; Shelby Kutty; Rebecca K Lindquist; Ling Li; Benjamin W Eidem Journal: J Am Soc Echocardiogr Date: 2012-05-10 Impact factor: 5.251
Authors: Daniel Overhoff; Uzair Ansari; Anna Hohneck; Erol Tülümen; Boris Rudic; Jürgen Kuschyk; Dirk Lossnitzer; Stefan Baumann; Matthias F Froelich; Stephan Waldeck; Ibrahim Akin; Martin Borggrefe; Stefan O Schoenberg; Theano Papavassiliu Journal: ESC Heart Fail Date: 2021-11-24