Literature DB >> 28874377

High-Level Resistance to Colistin Mediated by Various Mutations in the crrB Gene among Carbapenemase-Producing Klebsiella pneumoniae.

Aurélie Jayol1,2,3,4,5, Patrice Nordmann1,2,3,6, Adrian Brink7, Maria-Virginia Villegas8, Véronique Dubois4,5, Laurent Poirel9,2,3.   

Abstract

Mutations in crrAB genes encoding a two-component regulator involved in modifications of lipopolysaccharide were searched for among a collection of colistin-resistant Klebsiella pneumoniae isolates. Four isolates, respectively, producing carbapenemases NDM-1, OXA-181, or KPC-2 showed mutated CrrB proteins compared with those in wild-type strains. Complementation assays with a wild-type CrrB protein restored the susceptibility to colistin in all cases, confirming the involvement of the identified substitutions in the resistance phenotype.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  CrrAB; Klebsiella pneumoniae; polymyxin; rapid polymyxin NP test; resistance mechanisms; susceptibility testing

Mesh：

Substances：

Year:  2017        PMID： 28874377      PMCID： PMC5655078          DOI： 10.1128/AAC.01423-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

Review 1.  Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections.

Authors:  Matthew E Falagas; Sofia K Kasiakou
Journal:  Clin Infect Dis       Date:  2005-03-22       Impact factor: 9.079

Review 2.  Susceptibility testing of the polymyxins: where are we now?

Authors:  Romney M Humphries
Journal:  Pharmacotherapy       Date:  2014-10-20       Impact factor: 4.705

Review 3.  Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes.

Authors:  Laurent Poirel; Aurélie Jayol; Patrice Nordmann
Journal:  Clin Microbiol Rev       Date:  2017-04       Impact factor: 26.132

4.  Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016.

Authors:  Basil Britto Xavier; Christine Lammens; Rohit Ruhal; Samir Kumar-Singh; Patrick Butaye; Herman Goossens; Surbhi Malhotra-Kumar
Journal:  Euro Surveill       Date:  2016-07-07

5.  Genomic and transcriptomic analyses of colistin-resistant clinical isolates of Klebsiella pneumoniae reveal multiple pathways of resistance.

Authors:  Meredith S Wright; Yo Suzuki; Marcus B Jones; Steven H Marshall; Susan D Rudin; David van Duin; Keith Kaye; Michael R Jacobs; Robert A Bonomo; Mark D Adams
Journal:  Antimicrob Agents Chemother       Date:  2014-11-10       Impact factor: 5.191

6.  Heteroresistance to colistin in Klebsiella pneumoniae associated with alterations in the PhoPQ regulatory system.

Authors:  Aurélie Jayol; Patrice Nordmann; Adrian Brink; Laurent Poirel
Journal:  Antimicrob Agents Chemother       Date:  2015-03-02       Impact factor: 5.191

7.  Resistance to colistin associated with a single amino acid change in protein PmrB among Klebsiella pneumoniae isolates of worldwide origin.

Authors:  Aurélie Jayol; Laurent Poirel; Adrian Brink; Maria-Virginia Villegas; Mesut Yilmaz; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2014-06-09       Impact factor: 5.191

8.  Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.

Authors:  Yi-Yun Liu; Yang Wang; Timothy R Walsh; Ling-Xian Yi; Rong Zhang; James Spencer; Yohei Doi; Guobao Tian; Baolei Dong; Xianhui Huang; Lin-Feng Yu; Danxia Gu; Hongwei Ren; Xiaojie Chen; Luchao Lv; Dandan He; Hongwei Zhou; Zisen Liang; Jian-Hua Liu; Jianzhong Shen
Journal:  Lancet Infect Dis       Date:  2015-11-19       Impact factor: 25.071

9.  A novel selection marker for efficient DNA cloning and recombineering in E. coli.

Authors:  Chuan-Wei Jang; Terry Magnuson
Journal:  PLoS One       Date:  2013-02-20       Impact factor: 3.240

10.  Rapid Detection of Polymyxin Resistance in Enterobacteriaceae.

Authors:  Patrice Nordmann; Aurélie Jayol; Laurent Poirel
Journal:  Emerg Infect Dis       Date:  2016-06       Impact factor: 6.883
View more
  20 in total

1.  Proteomic Changes of Klebsiella pneumoniae in Response to Colistin Treatment and crrB Mutation-Mediated Colistin Resistance.

Authors:  Lang Sun; Pernille Kronholm Rasmussen; Yinlei Bai; Xiulan Chen; Tanxi Cai; Jifeng Wang; Xiaojing Guo; Zhensheng Xie; Xiang Ding; Lili Niu; Nali Zhu; Xuefu You; Finn Kirpekar; Fuquan Yang
Journal:  Antimicrob Agents Chemother       Date:  2020-05-21       Impact factor: 5.191

2.  Proteomic Investigation of the Signal Transduction Pathways Controlling Colistin Resistance in Klebsiella pneumoniae.

Authors:  Ching Hei Phoebe Cheung; Punyawee Dulyayangkul; Kate J Heesom; Matthew B Avison
Journal:  Antimicrob Agents Chemother       Date:  2020-07-22       Impact factor: 5.191

3.  Missense Mutations in the CrrB Protein Mediate Odilorhabdin Derivative Resistance in Klebsiella pneumoniae.

Authors:  Lucile Pantel; Paulo Juarez; Marine Serri; Lilia Boucinha; Emilie Lessoud; Anne Lanois; Alain Givaudan; Emilie Racine; Maxime Gualtieri
Journal:  Antimicrob Agents Chemother       Date:  2021-03-08       Impact factor: 5.191

4.  Phenotypic and Genotypic Characterization of ESBL-, AmpC-, and Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli Isolates.

Authors:  Hossein Kazemian; Hamid Heidari; Roya Ghanavati; Sobhan Ghafourian; Fateme Yazdani; Nourkhoda Sadeghifard; Hasan Valadbeigi; Abbas Maleki; Iraj Pakzad
Journal:  Med Princ Pract       Date:  2019-04-16       Impact factor: 1.927

5.  Polyclonal spread of colistin resistant Klebsiella pneumoniae in Croatian hospitals and outpatient setting.

Authors:  Tatjana Tot; Sara Kibel; Sanda Sardelić; Khalil Nemer; Ana Benčić; Jasmina Vraneš; Marija Krilanović; Marko Jelić; Marko Tripković; Marina Bubonja-Šonje; Branka Bedenić
Journal:  Germs       Date:  2021-06-02

6.  Mechanistic Insights to Combating NDM- and CTX-M-Coproducing Klebsiella pneumoniae by Targeting Cell Wall Synthesis and Outer Membrane Integrity.

Authors:  Nicholas M Smith; Katie Rose Boissonneault; Liang Chen; Vidmantas Petraitis; Ruta Petraitiene; Xun Tao; Jieqiang Zhou; Yinzhi Lang; Povilas Kavaliauskas; Zackery P Bulman; Patricia N Holden; Raymond Cha; Jürgen B Bulitta; Barry N Kreiswirth; Thomas J Walsh; Brian T Tsuji
Journal:  Antimicrob Agents Chemother       Date:  2022-08-04       Impact factor: 5.938

7.  Association Between Types of Carbapenemase and Clinical Outcomes of Infection Due to Carbapenem Resistance Enterobacterales.

Authors:  Korawan Pudpong; Sutthiporn Pattharachayakul; Wichai Santimaleeworagun; Ozioma F Nwabor; Varaporn Laohaprertthisan; Thanaporn Hortiwakul; Boonsri Charernmak; Sarunyou Chusri
Journal:  Infect Drug Resist       Date:  2022-06-13       Impact factor: 4.177

8.  A putative RND-type efflux pump, H239_3064, contributes to colistin resistance through CrrB in Klebsiella pneumoniae.

Authors:  Yi-Hsiang Cheng; Tzu-Lung Lin; Yi-Tsung Lin; Jin-Town Wang
Journal:  J Antimicrob Chemother       Date:  2018-06-01       Impact factor: 5.790

9.  Antibiotic resistance and detection of plasmid mediated colistin resistance mcr-1 gene among Escherichia coli and Klebsiella pneumoniae isolated from clinical samples.

Authors:  Deepa Karki; Binod Dhungel; Srijana Bhandari; Anil Kunwar; Prabhu Raj Joshi; Basudha Shrestha; Komal Raj Rijal; Prakash Ghimire; Megha Raj Banjara
Journal:  Gut Pathog       Date:  2021-07-05       Impact factor: 4.181

10.  Various Novel Colistin Resistance Mechanisms Interact To Facilitate Adaptation of Aeromonas hydrophila to Complex Colistin Environments.

Authors:  Junqi Liu; Gang Xiao; Wangping Zhou; Jun Yang; Yang Wang; Yong Wu; Xiaojun Cheng; Zhiliang Sun
Journal:  Antimicrob Agents Chemother       Date:  2021-06-17       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.