Devon J Boyne1,2, Christine M Friedenreich1,2,3, John B McIntyre4, Kerry S Courneya5, Will D King6. 1. Department of Cancer Epidemiology & Prevention Research, Cancer Control Alberta, Alberta Health Services, Calgary, AB, Canada. 2. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. 3. Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. 4. Translational Laboratory, Department of Pathology & Laboratory Medicine, Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada. 5. Faculty of Physical Education & Recreation, University of Alberta, Edmonton, AB, Canada. 6. Department of Public Health Sciences, Queen's University, Kingston, ON, Canada.
Abstract
AIM: To describe the association between adiposity and repetitive element DNA methylation in healthy postmenopausal women. PATIENTS & METHODS: A cross-sectional study was conducted using baseline information from 289 women who participated in the Alberta Physical Activity and Breast Cancer Prevention trial. RESULTS: After adjusting for important confounders, long interspersed nuclear element-1 methylation was positively associated with intra-abdominal fat area (p = 0.03), body fat percent (p = 0.048), fat mass (p = 0.01), waist circumference (p = 0.03), hip circumference (p = 0.001), BMI (p = 0.03), current weight (p = 0.002), weight at age 20 (p = 0.02) and adulthood weight gain (p = 0.03). No significant associations were found between any of the adiposity measures and Alu methylation. CONCLUSION: Current and historical adiposity measures are positively associated with long interspersed nuclear element-1 methylation in healthy postmenopausal women.
AIM: To describe the association between adiposity and repetitive element DNA methylation in healthy postmenopausal women. PATIENTS & METHODS: A cross-sectional study was conducted using baseline information from 289 women who participated in the Alberta Physical Activity and Breast Cancer Prevention trial. RESULTS: After adjusting for important confounders, long interspersed nuclear element-1 methylation was positively associated with intra-abdominal fat area (p = 0.03), body fat percent (p = 0.048), fat mass (p = 0.01), waist circumference (p = 0.03), hip circumference (p = 0.001), BMI (p = 0.03), current weight (p = 0.002), weight at age 20 (p = 0.02) and adulthood weight gain (p = 0.03). No significant associations were found between any of the adiposity measures and Alu methylation. CONCLUSION: Current and historical adiposity measures are positively associated with long interspersed nuclear element-1 methylation in healthy postmenopausal women.
Entities:
Keywords:
Alu; DNA methylation; LINE-1; adiposity; body fat; postmenopausal; repetitive elements
Authors: Ting Xie; Vesna Gorenjak; Maria G Stathopoulou; Sébastien Dadé; Eirini Marouli; Christine Masson; Helena Murray; John Lamont; Peter Fitzgerald; Panos Deloukas; Sophie Visvikis-Siest Journal: BMC Med Genomics Date: 2021-09-23 Impact factor: 3.063