Literature DB >> 28873104

Management of trauma and burn scars: the dermatologist's role in expanding patient access to care.

Nathanial R Miletta1, Matthias B Donelan2, Chad M Hivnor1.   

Abstract

Recent advances in laser surgery and our understanding of wound healing have ushered in a new era of trauma and burn scar management. Traditional therapy has centered around scar excision followed by primary closure or tissue replacement with flaps and grafts. This approach represents a perpetuation of the common fallacy that extensive scar improvement requires extensive surgical intervention. Laser surgery in conjunction with pharmacotherapy and minor tissue-conserving surgery produces well-healed and remodeled existing tissue that provides the most natural appearance and function of the skin. Now, patients' hypertrophic, contracted, and disfiguring scars represent their most valuable reconstructive anatomy. With this paradigm shift, dermatologists are uniquely positioned to provide transformative and cost-effective scar therapy due to their proficiency in the necessary treatment modalities and expertise in the utilization of local anesthesia. We hope to further expand military and civilian patient access to such care in their local community through peer education and advocacy. We present a brief overview and outline of scar treatment practices that can be performed by dermatologists in office using devices and techniques they often already possess.

Entities:  

Mesh:

Year:  2017        PMID: 28873104

Source DB:  PubMed          Journal:  Cutis        ISSN: 0011-4162


  6 in total

1.  MicroRNA-494 targets PTEN and suppresses PI3K/AKT pathway to alleviate hypertrophic scar formation.

Authors:  Ting He; Yue Zhang; Yang Liu; Hongtao Wang; Wanfu Zhang; Jiaqi Liu; Na Li; Yan Li; Luxu Wang; Songtao Xie; Dahai Hu
Journal:  J Mol Histol       Date:  2019-05-08       Impact factor: 2.611

2.  SJS/TEN 2019: From science to translation.

Authors:  Wan-Chun Chang; Riichiro Abe; Paul Anderson; Wanpen Anderson; Michael R Ardern-Jones; Thomas M Beachkofsky; Teresa Bellón; Agnieszka K Biala; Charles Bouchard; Gianpiero L Cavalleri; Nicole Chapman; James Chodosh; Hyon K Choi; Ricardo R Cibotti; Sherrie J Divito; Karen Dewar; Ulrike Dehaeck; Mahyar Etminan; Diane Forbes; Esther Fuchs; Jennifer L Goldman; James H Holmes; Elyse A Hope; Shuen-Iu Hung; Chia-Ling Hsieh; Alfonso Iovieno; Julienne Jagdeo; Mee Kum Kim; David M Koelle; Mario E Lacouture; Sophie Le Pallec; Rannakoe J Lehloenya; Robyn Lim; Angie Lowe; Jean McCawley; Julie McCawley; Robert G Micheletti; Maja Mockenhaupt; Katie Niemeyer; Michael A Norcross; Douglas Oboh; Cristina Olteanu; Helena B Pasieka; Jonathan Peter; Munir Pirmohamed; Michael Rieder; Hajirah N Saeed; Neil H Shear; Christine Shieh; Sabine Straus; Chonlaphat Sukasem; Cynthia Sung; Jason A Trubiano; Sheng-Ying Tsou; Mayumi Ueta; Simona Volpi; Chen Wan; Hongsheng Wang; Zhao-Qing Wang; Jessica Weintraub; Cindy Whale; Lisa M Wheatley; Sonia Whyte-Croasdaile; Kristina B Williams; Galen Wright; Sonia N Yeung; Li Zhou; Wen-Hung Chung; Elizabeth J Phillips; Bruce C Carleton
Journal:  J Dermatol Sci       Date:  2020-03-07       Impact factor: 4.563

3.  Treatment of burn scars in Fitzpatrick phototype III patients with a combination of pulsed dye laser and non-ablative fractional resurfacing 1550 nm erbium:glass/1927 nm thulium laser devices.

Authors:  Joy Tao; Amanda Champlain; Charles Weddington; Lauren Moy; Rebecca Tung
Journal:  Scars Burn Heal       Date:  2018-02-23

4.  Inhibition of sphingosine kinase 2 attenuates hypertrophic scar formation via upregulation of Smad7 in human hypertrophic scar fibroblasts.

Authors:  Jian Zeng; Bin Jiang; Xia Xiao; Rou Zhang
Journal:  Mol Med Rep       Date:  2020-07-09       Impact factor: 2.952

5.  Tetramethylpyrazine Induces Apoptosis and Inhibits Proliferation of Hypertrophic Scar-Derived Fibroblasts via Inhibiting the Phosphorylation of AKT.

Authors:  Xue Wu; Zheng Wang; Gaofeng Wu; Xiaofan Xu; Jian Zhang; Yan Li; Hong Zhang; Shuzhen Guo
Journal:  Front Pharmacol       Date:  2020-05-05       Impact factor: 5.810

6.  Silencing of long noncoding INHBA antisense RNA1 suppresses proliferation, migration, and extracellular matrix deposition in human hypertrophic scar fibroblasts via regulating microRNA-141-3p/myeloid cell leukemia 1 axis.

Authors:  Yan Yang; Chun Xiao; Kang Liu; Liping Song; Yonggang Zhang; Birong Dong
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269

  6 in total

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