Literature DB >> 28871376

[Branch duct intraductal papillary mucinous neoplasm - contra resection].

M Brunner1, G F Weber1, S Kersting1, Robert Grützmann2.   

Abstract

Due to improvements in imaging modalities the diagnosis of branch duct intraductal papillary mucinous neoplasms (BD-IPMN) has been significantly increased in recent years. A BD-IPMN is frequently diagnosed as an incidental finding in asymptomatic patients. The optimal management of BD-IPMN is the subject of controversial discussions. Numerous studies have shown that an individualized therapeutic strategy with a follow-up observation of most BD-IPMNs is feasible and safe, considering age, comorbidities and patient preference. An accurate evaluation of BD-IPMN with a detailed anamnesis, high-resolution imaging techniques and endoscopic ultrasound is necessary. Symptomatic patients as well as patients with so-called high-risk stigmata should undergo resection. Asymptomatic patients with so-called worrisome features can either undergo surveillance or surgical resection, taking age and comorbidities into account. For BD-IPMN patients without high-risk stigmata and worrisome features and showing no symptoms, surveillance of the pancreatic lesion is the preferred approach. The high prevalence of BD-IPMN, limitations in differential diagnostics, an overestimation of the risk of malignancy due to an overrepresentation of symptomatic and suspected BD-IPMN in resected cohorts, an overestimated role of BD-IPMN as precursor lesions for pancreatic carcinoma and evidence of the safety of follow-up surveillance, underline the enormous importance of surveillance. Based on this and considering the background of a notable mortality and morbidity of pancreatic surgery, aggressive management with prophylactic surgical resection is not justified for all BD-IPMN, in particular for low-risk lesions.

Entities:  

Keywords:  Malignancy risk; Pancreatic cysts; Pancreatic surgery; Prevalence; Surveillance

Mesh:

Year:  2017        PMID: 28871376     DOI: 10.1007/s00104-017-0495-z

Source DB:  PubMed          Journal:  Chirurg        ISSN: 0009-4722            Impact factor:   0.955


  30 in total

1.  One thousand consecutive pancreaticoduodenectomies.

Authors:  John L Cameron; Taylor S Riall; JoAnn Coleman; Kenneth A Belcher
Journal:  Ann Surg       Date:  2006-07       Impact factor: 12.969

Review 2.  International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas.

Authors:  Masao Tanaka; Suresh Chari; Volkan Adsay; Carlos Fernandez-del Castillo; Massimo Falconi; Michio Shimizu; Koji Yamaguchi; Kenji Yamao; Seiki Matsuno
Journal:  Pancreatology       Date:  2006       Impact factor: 3.996

Review 3.  Surgical Management of Pancreatic Cysts: A Shifting Paradigm Toward Selective Resection.

Authors:  Jon M Gerry; George A Poultsides
Journal:  Dig Dis Sci       Date:  2017-04-18       Impact factor: 3.199

4.  Comparison of preoperative conference-based diagnosis with histology of cystic tumors of the pancreas.

Authors:  Marco Del Chiaro; Ralf Segersvärd; Raffaella Pozzi Mucelli; Elena Rangelova; Nikolaos Kartalis; Christoph Ansorge; Urban Arnelo; John Blomberg; Matthias Löhr; Caroline Verbeke
Journal:  Ann Surg Oncol       Date:  2014-01-03       Impact factor: 5.344

5.  Pancreatic cysts: depiction on single-shot fast spin-echo MR images.

Authors:  Xiao-Ming Zhang; Donald G Mitchell; Masako Dohke; George A Holland; Laurence Parker
Journal:  Radiology       Date:  2002-05       Impact factor: 11.105

Review 6.  Risk of pancreatic malignancy and mortality in branch-duct IPMNs undergoing surveillance: A systematic review and meta-analysis.

Authors:  Stefano Crippa; Gabriele Capurso; Calogero Cammà; Gianfranco Delle Fave; Carlos Fernández-Del Castillo; Massimo Falconi
Journal:  Dig Liver Dis       Date:  2016-02-18       Impact factor: 4.088

7.  Cyst growth rate predicts malignancy in patients with branch duct intraductal papillary mucinous neoplasms.

Authors:  Mee Joo Kang; Jin-Young Jang; Soo Jin Kim; Kyoung Bun Lee; Ji Kon Ryu; Yong-Tae Kim; Yong Bum Yoon; Sun-Whe Kim
Journal:  Clin Gastroenterol Hepatol       Date:  2010-09-17       Impact factor: 11.382

8.  Malignant progression in IPMN: a cohort analysis of patients initially selected for resection or observation.

Authors:  J Lafemina; N Katabi; D Klimstra; C Correa-Gallego; S Gaujoux; T P Kingham; R P Dematteo; Y Fong; M I D'Angelica; W R Jarnagin; R K Do; M F Brennan; Peter J Allen
Journal:  Ann Surg Oncol       Date:  2012-10-31       Impact factor: 5.344

9.  Prevalence of unsuspected pancreatic cysts on MDCT.

Authors:  Thomas A Laffan; Karen M Horton; Alison P Klein; Bruce Berlanstein; Stanley S Siegelman; Satomi Kawamoto; Pamela T Johnson; Elliot K Fishman; Ralph H Hruban
Journal:  AJR Am J Roentgenol       Date:  2008-09       Impact factor: 3.959

10.  Branch-duct intraductal papillary mucinous neoplasms: observations in 145 patients who underwent resection.

Authors:  J Ruben Rodriguez; Roberto Salvia; Stefano Crippa; Andrew L Warshaw; Claudio Bassi; Massimo Falconi; Sarah P Thayer; Gregory Y Lauwers; Paola Capelli; Mari Mino-Kenudson; Oswaldo Razo; Deborah McGrath; Paolo Pederzoli; Carlos Fernández-Del Castillo
Journal:  Gastroenterology       Date:  2007-05-10       Impact factor: 22.682

View more
  2 in total

Review 1.  [Pancreatic cystic space-occupying lesions-Diagnostics, treatment and follow-up care : Current recommendations taking the current German S3 guidelines on pancreatic cancer into account].

Authors:  Maximilian Brunner; Lena Häberle; Irene Esposito; Robert Grützmann
Journal:  Chirurg       Date:  2022-03-22       Impact factor: 0.955

2.  Management and outcomes of intraductal papillary mucinous neoplasms.

Authors:  J Hipp; S Mohamed; J Pott; O Sick; F Makowiec; U T Hopt; S Fichtner-Feigl; U A Wittel
Journal:  BJS Open       Date:  2019-03-21
  2 in total

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