Literature DB >> 28871312

ALK1 signaling in development and disease: new paradigms.

Beth L Roman1, Andrew P Hinck2.   

Abstract

Activin A receptor like type 1 (ALK1) is a transmembrane serine/threonine receptor kinase in the transforming growth factor-beta receptor family that is expressed on endothelial cells. Defects in ALK1 signaling cause the autosomal dominant vascular disorder, hereditary hemorrhagic telangiectasia (HHT), which is characterized by development of direct connections between arteries and veins, or arteriovenous malformations (AVMs). Although previous studies have implicated ALK1 in various aspects of sprouting angiogenesis, including tip/stalk cell selection, migration, and proliferation, recent work suggests an intriguing role for ALK1 in transducing a flow-based signal that governs directed endothelial cell migration within patent, perfused vessels. In this review, we present an updated view of the mechanism of ALK1 signaling, put forth a unified hypothesis to explain the cellular missteps that lead to AVMs associated with ALK1 deficiency, and discuss emerging roles for ALK1 signaling in diseases beyond HHT.

Entities:  

Keywords:  Activin A receptor like type 1; Angiogenesis; Arteriovenous malformation; Bone morphogenetic protein; Endoglin; Hereditary hemorrhagic telangiectasia

Mesh：

Substances：

Year:  2017        PMID： 28871312      PMCID： PMC5687069          DOI： 10.1007/s00018-017-2636-4

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  266 in total

Review 1.  Structural Biology and Evolution of the TGF-β Family.

Authors:  Andrew P Hinck; Thomas D Mueller; Timothy A Springer
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-12-01       Impact factor: 10.005

2.  Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells.

Authors:  Laurent David; Christine Mallet; Sabine Mazerbourg; Jean-Jacques Feige; Sabine Bailly
Journal:  Blood       Date:  2006-10-26       Impact factor: 22.113

3.  Conditional knockout of activin like kinase-1 (ALK-1) leads to heart failure without maladaptive remodeling.

Authors:  Kevin J Morine; Xiaoying Qiao; Vikram Paruchuri; Mark J Aronovitz; Emily E Mackey; Lyanne Buiten; Jonathan Levine; Keshan Ughreja; Prerna Nepali; Robert M Blanton; Richard H Karas; S Paul Oh; Navin K Kapur
Journal:  Heart Vessels       Date:  2017-02-17       Impact factor: 2.037

4.  Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1.

Authors:  A Lux; L Attisano; D A Marchuk
Journal:  J Biol Chem       Date:  1999-04-09       Impact factor: 5.157

5.  The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation.

Authors:  U Persson; H Izumi; S Souchelnytskyi; S Itoh; S Grimsby; U Engström; C H Heldin; K Funa; P ten Dijke
Journal:  FEBS Lett       Date:  1998-08-28       Impact factor: 4.124

6.  Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis.

Authors:  Satoshi Somekawa; Keiichi Imagawa; Hisaki Hayashi; Masahide Sakabe; Tomoko Ioka; Genki E Sato; Ken Inada; Takaaki Iwamoto; Toshio Mori; Shiro Uemura; Osamu Nakagawa; Yoshihiko Saito
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-10       Impact factor: 11.205

7.  Crystal structure of BMP-9 and functional interactions with pro-region and receptors.

Authors:  Monica A Brown; Qinghai Zhao; Kent A Baker; Chethana Naik; Cecil Chen; Laurie Pukac; Mallika Singh; Tatiana Tsareva; Yanick Parice; Angela Mahoney; Viktor Roschke; Indra Sanyal; Senyon Choe
Journal:  J Biol Chem       Date:  2005-04-25       Impact factor: 5.157

8.  Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis.

Authors:  Amy L Akers; Eric Johnson; Gary K Steinberg; Joseph M Zabramski; Douglas A Marchuk
Journal:  Hum Mol Genet       Date:  2008-12-16       Impact factor: 6.150

9.  Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4.

Authors:  H U Wang; Z F Chen; D J Anderson
Journal:  Cell       Date:  1998-05-29       Impact factor: 41.582

10.  Phase II evaluation of dalantercept, a soluble recombinant activin receptor-like kinase 1 (ALK1) receptor fusion protein, for the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study 0229N.

Authors:  Vicky Makker; Virginia L Filiaci; Lee-May Chen; Christopher J Darus; James E Kendrick; Gregory Sutton; Katherine Moxley; Carol Aghajanian
Journal:  Gynecol Oncol       Date:  2015-04-16       Impact factor: 5.482
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  24 in total

Review 1.  Veins and Arteries Build Hierarchical Branching Patterns Differently: Bottom-Up versus Top-Down.

Authors:  Kristy Red-Horse; Arndt F Siekmann
Journal:  Bioessays       Date:  2019-03       Impact factor: 4.345

2.  Immunohistochemical Analysis of Activin Receptor-Like Kinase 1 (ACVRL1/ALK1) Expression in the Rat and Human Hippocampus: Decline in CA3 During Progression of Alzheimer's Disease.

Authors:  Stephanie L Adams; Laurent Benayoun; Kathy Tilton; Tiffany J Mellott; Sudha Seshadri; Jan Krzysztof Blusztajn; Ivana Delalle
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

Review 3.  Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family.

Authors:  Sun Kyung Kim; Morkos A Henen; Andrew P Hinck
Journal:  Exp Biol Med (Maywood)       Date:  2019-10-10

4.  Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract.

Authors:  Pragya Sidhwani; Dena M Leerberg; Giulia L M Boezio; Teresa L Capasso; Hongbo Yang; Neil C Chi; Beth L Roman; Didier Y R Stainier; Deborah Yelon
Journal:  Development       Date:  2020-06-17       Impact factor: 6.868

5.  Structural Adaptation in Its Orphan Domain Engenders Betaglycan with an Alternate Mode of Growth Factor Binding Relative to Endoglin.

Authors:  Sun Kyung Kim; Matthew J Whitley; Troy C Krzysiak; Cynthia S Hinck; Alexander B Taylor; Christian Zwieb; Chang-Hyeock Byeon; Xiaohong Zhou; Valentín Mendoza; Fernando López-Casillas; William Furey; Andrew P Hinck
Journal:  Structure       Date:  2019-07-18       Impact factor: 5.006

6.  Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models.

Authors:  Santiago Ruiz; Haitian Zhao; Pallavi Chandakkar; Julien Papoin; Hyunwoo Choi; Aya Nomura-Kitabayashi; Radhika Patel; Matthew Gillen; Li Diao; Prodyot K Chatterjee; Mingzhu He; Yousef Al-Abed; Ping Wang; Christine N Metz; S Paul Oh; Lionel Blanc; Fabien Campagne; Philippe Marambaud
Journal:  J Clin Invest       Date:  2020-02-03       Impact factor: 14.808

7.  SMAD4 Prevents Flow Induced Arteriovenous Malformations by Inhibiting Casein Kinase 2.

Authors:  Roxana Ola; Sandrine H Künzel; Feng Zhang; Gael Genet; Raja Chakraborty; Laurence Pibouin-Fragner; Kathleen Martin; William Sessa; Alexandre Dubrac; Anne Eichmann
Journal:  Circulation       Date:  2018-11-20       Impact factor: 29.690

8.  BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance.

Authors:  Teresa L Capasso; Bijun Li; Harry J Volek; Waqas Khalid; Elizabeth R Rochon; Arulselvi Anbalagan; Chelsea Herdman; H Joseph Yost; Flordeliza S Villanueva; Kang Kim; Beth L Roman
Journal:  Angiogenesis       Date:  2019-12-11       Impact factor: 9.596

9.  ALK1 regulates the internalization of endoglin and the type III TGF-β receptor.

Authors:  Keren Tazat; Leslie Pomeraniec-Abudy; Melissa Hector-Greene; Szabina Szófia Szilágyi; Swati Sharma; Elise M Cai; Armando L Corona; Marcelo Ehrlich; Gerard C Blobe; Yoav I Henis
Journal:  Mol Biol Cell       Date:  2021-02-10       Impact factor: 4.138

10.  In Search of "Hepatic Factor": Lack of Evidence for ALK1 Ligands BMP9 and BMP10.

Authors:  Teresa L Capasso; Sara M Trucco; Morgan Hindes; Tristin Schwartze; Jamie L Bloch; Jacqueline Kreutzer; Stephen C Cook; Cynthia S Hinck; Davide Treggiari; Brian Feingold; Andrew P Hinck; Beth L Roman
Journal:  Am J Respir Crit Care Med       Date:  2021-01-15       Impact factor: 21.405
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