Q I Fang1, Xufen Wang1, Guanghua Luo2, Miaomei Yu2, Xiaoying Zhang3, Ning Xu4. 1. Department of Breast Surgery, the Third Affiliated Hospital of Soochow University, Changzhou, P.R. China. 2. Department of Comprehensive Laboratory, the Third Affiliated Hospital of Soochow University, Changzhou, P.R. China. 3. Department of Comprehensive Laboratory, the Third Affiliated Hospital of Soochow University, Changzhou, P.R. China zhangxy6689996@163.com ning.xu@med.lu.se. 4. Division of Clinical Chemistry and Pharmacology, Department of Laboratory Medicine, Lund University, Lund, Sweden zhangxy6689996@163.com ning.xu@med.lu.se.
Abstract
BACKGROUND: C-X-C motif chemokine ligand 8 (CXCL8) is a multi-functional chemokine and has important roles during tumor formation and development. It was previously reported that increased CXCL8 protein levels occurred in certain patients. MATERIALS AND METHODS: In the present study, we examined levels of CXCL8 mRNA in breast cancer tissues and analyzed its levels in correlation to patients' clinical data and 10-year overall survival (OS). RESULTS: Our results clearly demonstrated that the level of CXCL8 mRNA was significantly higher in patients without estrogen receptor expression. The receiver operating characteristic curve indicated that the best cut-off value for CXCL8 expression was 3.095 for predicting patient's OS. CONCLUSION: The present study demonstrated that higher CXCL8 mRNA levels in breast cancer tissues together with estrogen receptor negativity was associated with significantly shorter OS, and could be applied as a negative risk factor for 10-year OS. Copyright
BACKGROUND:C-X-C motif chemokine ligand 8 (CXCL8) is a multi-functional chemokine and has important roles during tumor formation and development. It was previously reported that increased CXCL8 protein levels occurred in certain patients. MATERIALS AND METHODS: In the present study, we examined levels of CXCL8 mRNA in breast cancer tissues and analyzed its levels in correlation to patients' clinical data and 10-year overall survival (OS). RESULTS: Our results clearly demonstrated that the level of CXCL8 mRNA was significantly higher in patients without estrogen receptor expression. The receiver operating characteristic curve indicated that the best cut-off value for CXCL8 expression was 3.095 for predicting patient's OS. CONCLUSION: The present study demonstrated that higher CXCL8 mRNA levels in breast cancer tissues together with estrogen receptor negativity was associated with significantly shorter OS, and could be applied as a negative risk factor for 10-year OS. Copyright