C Daraï1, S Bendifallah2, H Foulot3, M Ballester4, N Chabbert-Buffet4, E Daraï4. 1. Service de gynécologie-obstétrique et reproduction humaine, hôpital Tenon, université Pierre-et-Marie-Curie (UPMC), Assistance publique-Hôpitaux de Paris, Paris 6, 4, rue de La Chine, 75020 Paris, France; Groupe de recherche clinique (GRC-6 UPMC), centre expert en endométriose (C3E), hôpital Tenon, 75020 Paris, France; Cabinet d'ostéopathie, 1, rue Godefroy, 75013 Paris, France. 2. Service de gynécologie-obstétrique et reproduction humaine, hôpital Tenon, université Pierre-et-Marie-Curie (UPMC), Assistance publique-Hôpitaux de Paris, Paris 6, 4, rue de La Chine, 75020 Paris, France; Groupe de recherche clinique (GRC-6 UPMC), centre expert en endométriose (C3E), hôpital Tenon, 75020 Paris, France. Electronic address: sofiane.bendifallah@aphp.fr. 3. Service de gynécologie-obstétrique et reproduction humaine, hôpital Cochin Port-Royal, université René Descartes Paris 5, Assistance publique-Hôpitaux de Paris, 75014 Paris, France. 4. Service de gynécologie-obstétrique et reproduction humaine, hôpital Tenon, université Pierre-et-Marie-Curie (UPMC), Assistance publique-Hôpitaux de Paris, Paris 6, 4, rue de La Chine, 75020 Paris, France; Groupe de recherche clinique (GRC-6 UPMC), centre expert en endométriose (C3E), hôpital Tenon, 75020 Paris, France; UMRS-938, université Pierre-et-Marie-Curie, Paris 6, 75012 Paris, France.
Abstract
OBJECTIVES: A prospective study to evaluate the clinical impact of osteopathic manipulative therapy (OMT) on symptoms and quality of life (QOL) of patients with colorectal endometriosis. METHODS: Forty-six patients with colorectal endometriosis completed the SF-36 QOL and symptoms questionnaire before and after OMT. A comparison and clustering analysis was performed to identify subgroups of patient's profile and symptom classification. RESULTS: The mean age of the patients was 32±6.2 years. Prior surgery for endometriosis was recorded in 73.9 % of cases but none for deep infiltrating endometriosis. About three-quarters of the patients were nulliparous. The time between pre- and post-OMT completion of questionnaires was 28 days (15-63), A significant improvement in SF-36 QOL physical component summary (P<0.001) and mental component summary (P<0.001) was observed after OMT. Similarly, a significant improvement in gynecological, digestive and general symptoms values was observed. A clustering analysis allowed to identify four profiles of patients with colorectal endometriosis based on symptoms and a respective OMT gain of 30 %, 60 %, 64 % et 45 %. CONCLUSIONS: Our results support that OMT improve QOL and endometriosis symptoms of patients with colorectal endometriosis. Moreover, this symptom classification based on OMT gain can serve to design future randomized trial.
OBJECTIVES: A prospective study to evaluate the clinical impact of osteopathic manipulative therapy (OMT) on symptoms and quality of life (QOL) of patients with colorectal endometriosis. METHODS: Forty-six patients with colorectal endometriosis completed the SF-36 QOL and symptoms questionnaire before and after OMT. A comparison and clustering analysis was performed to identify subgroups of patient's profile and symptom classification. RESULTS: The mean age of the patients was 32±6.2 years. Prior surgery for endometriosis was recorded in 73.9 % of cases but none for deep infiltrating endometriosis. About three-quarters of the patients were nulliparous. The time between pre- and post-OMT completion of questionnaires was 28 days (15-63), A significant improvement in SF-36 QOL physical component summary (P<0.001) and mental component summary (P<0.001) was observed after OMT. Similarly, a significant improvement in gynecological, digestive and general symptoms values was observed. A clustering analysis allowed to identify four profiles of patients with colorectal endometriosis based on symptoms and a respective OMT gain of 30 %, 60 %, 64 % et 45 %. CONCLUSIONS: Our results support that OMT improve QOL and endometriosis symptoms of patients with colorectal endometriosis. Moreover, this symptom classification based on OMT gain can serve to design future randomized trial.