Erika Amore1, Maria Ferraro2, Maria Letizia Manca3, Mark Gjomarkaj2, Gaetano Giammona1, Elisabetta Pace2, Maria Luisa Bondì4. 1. Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy. 2. Istituto di Biomedicina e Immunologia Molecolare (IBIM), CNR, Via Ugo La Malfa 153, 90146 Palermo, Italy. 3. Dipartimento Scienze della Vita e dell'Ambiente, Sezione Scienze del Farmaco, Università degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, Italy. 4. Istituto per lo Studio dei Materiali Nanostrutturati (ISMN), U.O.S. Palermo, CNR, Via Ugo La Malfa 153, 90146 Palermo, Italy.
Abstract
AIM: Therapeutic efficacy of pulmonary diseases is often limited and drug delivery systems offer new solutions to clinical problems. Solid lipid microparticles (SLMs) are suggested as systems for the delivery of therapeutics to the lung as, because of their size, they are able to deposit into secondary bronchi. MATERIALS & METHODS: Here, we describe two novel different SLMs using chitosan and alginate such as mucoadhesive polymers and we also studied their biocompatibility and their effectiveness compared with the free drug in controlling senescence and inflammatory processes in cigarette smoke extracts. RESULTS: Data reported show that fluticasone propionate (FP)-loaded SLMs are more effective than FP alone in controlling oxidative stress. CONCLUSION: The therapeutic approach using FP-loaded microparticles could be a promising strategy for the treatment of the chronic inflammatory pulmonary diseases.
AIM: Therapeutic efficacy of pulmonary diseases is often limited and drug delivery systems offer new solutions to clinical problems. Solid lipid microparticles (SLMs) are suggested as systems for the delivery of therapeutics to the lung as, because of their size, they are able to deposit into secondary bronchi. MATERIALS & METHODS: Here, we describe two novel different SLMs using chitosan and alginate such as mucoadhesive polymers and we also studied their biocompatibility and their effectiveness compared with the free drug in controlling senescence and inflammatory processes in cigarette smoke extracts. RESULTS: Data reported show that fluticasone propionate (FP)-loaded SLMs are more effective than FP alone in controlling oxidative stress. CONCLUSION: The therapeutic approach using FP-loaded microparticles could be a promising strategy for the treatment of the chronic inflammatory pulmonary diseases.
Authors: Narasimha M Beeraka; Runze Zhou; Xiaoyan Wang; Hemanth Vikram P R; Tegginamath Pramod Kumar; Junqi Liu; M V Greeshma; Subhankar P Mandal; B M Gurupadayya; Ruitai Fan Journal: Int J Nanomedicine Date: 2022-05-12
Authors: Duaa A Dakhlallah; Jon Wisler; Marieta Gencheva; Candice M Brown; Erin R Leatherman; Kanhaiya Singh; Kathy Brundage; Todd Karsies; Ahmad Dakhlallah; Kenneth W Witwer; Chandan K Sen; Timothy D Eubank; Clay B Marsh Journal: J Extracell Vesicles Date: 2019-09-28